radiation dose Articles

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Clinical significance of low-dose radiation therapy: radiation hormesis

by Inderscience Publishers  (Dec. 27, 2010)

This study was designed to investigate the clinical significance of low-dose radiation therapy, radiation hormesis, and accuracy of therapeutic regimen. Radiation hormesis was performed in six patients (four patients with malignant diseases and two patients with benign diseases) in the experimental room where they could be exposed to a low level ...

Low-dose radiation risk and the linear no-threshold model

by Inderscience Publishers  (Sep. 21, 2009)

The Linear No-Threshold (LNT) model has been traditionally used in the field of radiation safety. Public attention to and debate on this model increased after estimates that current Computed Tomography (CT) procedures in the USA will ultimately be responsible for up to 2% of cancers. However, there is evidence that in the mGy range, low doses not ...

Suicides and exposure to low doses of ionising radiation

by Inderscience Publishers  (Nov. 21, 2007)

The suicide rates in southern India are very high (Joseph et al., 2003; Aaron et al., 2004), where there are areas of high natural radiation background (UNSCEAR, 2000). It was a stable tendency towards excess of suicides among the atomic bomb survivors exposed to low doses (0?90 mGy) (Kusumi et al., 1993). It was informed about the direct ...

DNA repair after low doses of ionising radiation

by Inderscience Publishers  (Jan. 10, 2007)

Exposure of mammalian cells to Ionising Radiation (IR) results in an integrated cellular response in which the activation of cell-cycle checkpoints is coordinated with DNA-repair pathways to optimise the removal of potentially cytotoxic or mutagenic DNA lesions. Radiobiological models have usually been based on observations of the cellular ...

Experimental studies on the biological effects of low-dose-rate and low-dose radiation

by Inderscience Publishers  (Jun. 19, 2008)

A lifespan study using a total of 4000 adult Specific Pathogen-Free (SPF) mice indicated that continuous gamma-ray exposures of both females and males for approximately 400 days at a dose rate of 20 mGy/day induced significant life shortening, mainly due to early neoplastic death, but no significant differences were found after exposure at a dose ...

A model for low dose effects of low-LET radiation delivered at high dose rates

by Inderscience Publishers  (Jan. 10, 2007)

In vitro studies show that protective tumour-reducing effects occur for low dose rates (mGy per minute). To account for these phenomena, we have previously developed stochastic and deterministic multi-stage cancer models that include radiation-induced adaptations in DNA repair processes and radical scavenging. Here, these models are extended to ...

Threshold dose problems in radiation carcinogenesis: a review of non-tumour doses

by Inderscience Publishers  (Oct. 4, 2004)

Non-tumour-inducing doses exist in dose-response data on experimental animals and humans, although a linear non-threshold model has been adopted for estimating cancer risk of ionising radiation at a low dose region for radiation protection purposes. Here, data on non- tumour dose, Dnt, the maximum dose at which a statistically significant increase ...

Radiation-induced apoptosis in SCID mouse spleen after low dose or low dose-rate irradiation

by Inderscience Publishers  (Feb. 24, 2004)

Concerning human health, studies of radioadaptive responses are quite important in radiation biology, because the radiation response may strongly depend on previous radiation exposure. Therefore, we have studied the radiation-induced Bax and apoptosis in mouse spleen after whole-body irradiation with low dose or low dose-rate. By use of severe ...

Epistemology on the attribution of radiation risks and effects to low radiation dose exposure situations

by Inderscience Publishers  (Apr. 2, 2012)

The epistemology on the attribution of radiation risks and effects relates to the theories of knowledge applied for assigning harm to radiation exposure, especially with regard to methods, validity and scope. The attribution of radiation risk is associated with the concept of probability, including the plausibility of whether there is risk in ...

A computational model for low-dose radiation induced cellular transformation by different radiation quantity

by Inderscience Publishers  (Dec. 13, 2011)

In this study, a new mechanism model is constructed to fit the experimental data from different radiation quantities. The aim of the study was to construct a comprehensive model that contained all the essential biological mechanisms, such as direct irradiation effects or bystander effects, induced DNA damage, Double-Strand Break (DSB) error-free ...

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