Analysis of Isocyanates Using the ASSET™ EZ4-NCO Dry Sampler - Health and Safety

Isocyanates are used as a raw material to produce a number of products . Personal exposure can occur while the products made with isocyanates are being applied, or when the materials are removed by grinding or thermal degradation. Workers who are exposed to these compounds are at risk for respiratory disorders and asthma. The highly reactive nature of the isocyanate compounds and the low occupational exposure limits put high demands on both sampling and analytical techniques for monitoring of isocyanates in air. We investigated the performance of the LC-MS and LC-MS-MS methods in the analysis of isocyanates using the new ASSET™ EZ4-NCO Dry Sampler. We found that the analytical method can successfully reach the quantitation limit for most isocyanates of 5 ng/mL in the final sample when LC-MS-MS analysis was used and the quantitation limit of 10 ng/mL when LC-MS analysis was used. All 11 compounds were well-resolved chromatographically using a 15 cm Ascentis Express C18 column.