Fermentation Off-Gas Analysis - pharmaceutical industry

In pilot plant and production scale fermentors, information relating to yield of product is of high importance. Hiden's gas analysers are configured with a multiport Off-Gas analysis manifold enabling simultaneous sampling from multiple fermentors. Data is used for the calculation of the respiratory quotient, carbon production rate and oxygen uptake rate. The Off-Gas measurement provides the respiratory quotient in a time and space averaged form and with good response time. By comparison data from multiple dissolved species probes are more specific and can provide information about stirring efficiency, aeration and feed distribution within the fermentor. Dissolved gas measurements have the advantage of giving direct information on gas uptake and for dissolved output rates. Hiden Analyticaloffers systems with either Off-Gas or dissolved species inlets or both.