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process analytical technology Applications

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    AutoChem - Process Analytical Technology (PAT)/Quality by Design (QbD)

    Process Analytical Technology (PAT) has been implemented for years, particularly by the chemical industry for the control of chemical processes. More recently, PAT has become a cornerstone of the US Food and Drug Administration’s (US FDA) Quality by Design (QbD) initiative for both the design and control of quality processes. For this reason, the pharmaceutical industry is also active in utilizing PAT tools. PAT tools can be implemented in both the lab and the plant, with laboratory PAT focused more on the design of a quality process and with plant PAT focused on the monitoring and control of the process.

    By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

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    Process Control for the Pharmaceutical Industry

    Current pharmaceutical manufacturing practices would be impossible without the benefits of Process Analytical Technology (PAT) which became a framework for bottom line process understanding. The cornerstones of the PAT approach —multivariate data acquisition, process/endpoint monitoring and process analytical chemistry— are included in the AppliTek philosophy for pharmaceutical applications. Understanding and enhancing the process by our analytical solutions is our goal and, above all, your success.

    By AppliTek NV based in Nazareth, BELGIUM.

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    AutoChem - Formulations and Product Development

    The particle size distribution is one of the most critical parameters in drug product quality. Real time understanding and control of particles ensures Quality by Design (QbD) in solid and liquid dosage formulation. FBRM and PVM Process Analytical Technologies (PAT) provide in-process real time measurements of particle dimension, particle shape, and particle count. FBRM and PVM are used to promote faster formulation development, improve process confidence, and control batch-to-batch consistency.

    By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

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    Online Monitoring for the Food & Beverage Industry

    Several on-line monitoring technologies such as non-destructive types have become increasingly important due to the increasing automation and the incorporation of new and more efficient processes in the food industry. Food quality and safety of food are the main points of interest. AppliTek builds and supplies the necessary analytical tools that will allow for a high throughput and a short response time to increase process efficiency and reduce waste, with seamless integration in the existing infrastructure.

    By AppliTek NV based in Nazareth, BELGIUM.

  • Environmental Monitoring

    Environmental monitoring is becoming more important every day in local, national and international policies, showing the environmental awareness demanded by society.

    This fact gives rise to an increase in the amount of legislation that obliges companies to law enforcement. Thus, the necessity of making more pollutants controls means high analysis expenses to the companies, which need to subcontract this service.

    Although applications in this area advance, there is still a clear demand to get new portable and versatile analysis systems for many different application fields such as pollution in environmental or waste waters, monitoring nutrients in agricultural or horticultural water as well as general process control in chemistry industry. Because of the number of enviromental analysis required, there is a need for screening and monitoring measurements of these compounds at contaminated areas.

    Traditional monitoring techniques are typically based on laboratory analysis of field-collected samples that require considerable effort and expense, and the sample may change before analysis. Moreover, the equipment currently available is too large and expensive and it cannot be made portable.Alternatively, microfluidic and electrochemical sensor technologies can contribute to the development of new portable monitoring systems, complementing standard analytical methods for different environmental monitoring applications.In this way, the decentralization and integration of all those typical analyses is the paramount importance in order to reduce cost, simplify the analytical process and make more accessible these technologies to end-users. The development of portable, robust, and accurate Lab-on-a-Chip systems to monitor priority compounds such as contaminants, explosives, chemical warfare agents, inorganic and organic ions is a demand of modern society. Portability allows analyses to be carried out outside of the laboratory, minimizing the risk of contaminating the sample and leading to a faster response time at a lower cost.

    Thus, MicruX solutions and technologies open the gate to develop portable and esay-handly Lab-on-a-Chip devices in order to improve pollutants in-situ analysis in a very economic and efficient way.

    By MicruX Technologies based in Oviedo, SPAIN.

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