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protein electrophoresis Applications

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    Determination of protein purity and heterogeneity with capillary gel electrophoresis and capillary isoelectric focusing

    INTRODUCTION Antibodies, protein-based therapeutics, and other recombinant proteins are final products in biotechnological and pharmaceutical industry. Determination of their purity, stability, and hetero geneity is of utmost importance since post-translational modifications as well as degradation processes can change drastically the biological activity of these proteins.

    By Lumex Instruments Group based in Mission, BRITISH COLUMBIA (CANADA).

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    Determination of serum protein fractions

    INTRODUCTION The method allows determination of relative amou nts of albumin and globulins in human serum using capillary electrophoresis methods.

    By Lumex Instruments Group based in Mission, BRITISH COLUMBIA (CANADA).

  • Empowering Traditional Mass Spectrometry System for Biotherapeutics

    Protein-based therapeutics cover a wide range of molecular types, including monoclonal antibodies (mAbs), Fc fusion proteins, and mAbs conjugated with small molecule drugs. The development of protein therapeutics is challenging and requires sensitive analytical techniques. Mass spectrometry (MS) is widely used due to its sensitivity, selectivity, and specificity. MS analysis can now be simplified and automated by integrating this powerful analytical technique with a microfluidic device that incorporates zone...

    By 908 Devices Inc. based in Boston, MASSACHUSETTS (USA).

  • Empowering Traditional Mass Spectrometry System for Proteomics & Peptide Mapping

    Peptide mapping is an essential step in the structural verification of recombinant proteins and biotherapeutic molecules. In this technique, proteins are digested into peptides, fractionated by traditional liquid chromatography (LC) methods and then analyzed by Mass Spectrometry (MS). Although this approach can be effective for many peptides, it is slow (often 30 minutes or more per sample), requires complex sample preparation and is incompatible with some sample types such as “sticky” peptides. The...

    By 908 Devices Inc. based in Boston, MASSACHUSETTS (USA).

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