Applications

Fluence has decades of experience delivering sustainable water and wastewater solutions to communities large and small. Fluence has more than 30 years of experience in the design, construction, and operation of water and wastewater treatment plants for municipal clients, government entities, communities, emergency relief, and private use.

By Fluence Corporation based in White Plains, NEW YORK (USA).

Fluence has decades of experience delivering cost-effective and sustainable treatment solutions for a wide range of industries.

By Fluence Corporation based in White Plains, NEW YORK (USA).

With predefined formulas or concentration tables the density meter converts the measured density value automatically into the desired concentration unit. The density meters from Mettler Toledo have already built in formulas and concentration tables for the most common applications.

By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

To ensure data integrity regular pipette performance testing and pipette calibration are fundamental to monitor the accuracy of your pipettes. Testing pipette performance with a balance plays a critical part in this testing approach. METTLER TOLEDO offers solutions for occasional performance testing up to professional pipette calibration according to ISO8655. We can support you in finding the right mix between self made pipette calibration and professional service support tailored to your needs.

By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

Simply connect one or multiple balances to the LabX balance PC software, define duration and frequency of your measurements and LabX takes care of automatic data collection. All weighings can be activated from the balance touch screen, executed according to your SOP and recorded automatically. LabX captures all data and stores it in a central SQL-database. From you office, you gain access to all data immediately and enjoy powerful data management functionalities. Data can also be exported manually or automatically to any destination, e.g. to a validated MS Excel spreadsheet or an application software.

By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

Optimize Multiphase Processes With In Situ Video and Real-Time Particle and Droplet Measurements. Particles and droplets are everywhere in the chemical, consumer products, pulp and paper, and petroleum industries. Particles grow, agglomerate, break, dissolve, and change shape - all of which can have an impact on process performance and product quality. To be successful, chemists and engineers must understand and optimize particle size distributions to control process efficiency such as stability, separations, or flow properties. In addition, particle and emulsion distributions must be well controlled to ensure repeatable product yield, shelf life, and bulk density.

By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

Process Analytical Technology (PAT) has been implemented for years, particularly by the chemical industry for the control of chemical processes. More recently, PAT has become a cornerstone of the US Food and Drug Administration’s (US FDA) Quality by Design (QbD) initiative for both the design and control of quality processes. For this reason, the pharmaceutical industry is also active in utilizing PAT tools. PAT tools can be implemented in both the lab and the plant, with laboratory PAT focused more on the design of a quality process and with plant PAT focused on the monitoring and control of the process.

By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

The particle size distribution is one of the most critical parameters in drug product quality. Real time understanding and control of particles ensures Quality by Design (QbD) in solid and liquid dosage formulation. FBRM and PVM Process Analytical Technologies (PAT) provide in-process real time measurements of particle dimension, particle shape, and particle count. FBRM and PVM are used to promote faster formulation development, improve process confidence, and control batch-to-batch consistency.

By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

Today, pharmaceutical and fine chemical companies face major challenges posed by globalization, environmental regulation, and shortened product life cycle that affect all aspects of their business. The research and development of an optimized chemical synthesis route must be carried out in less time and with less chemical waste to ensure a robust and economic process that can be efficiently scaled to manufacturing while meeting constraints related to product yield and purity, process and worker safety, and environmental concerns.

By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

Andreas Breidbach [1] and Wolfgang Brodacz [2,3,4] developed a new GC-MS method using fully 13C isotopelabelled analogues of T-2 toxin and HT-2 toxin that allows for the detection of these toxins at concentrations as low as 2–5 ppb.

By Merck KGaA, Darmstadt, Germany based in Darmstadt, GERMANY.

Beverages, such as sodas and energy drinks, can include a number of polar ingredients, which are easily soluble in the water matrix of the drinks. These ingredients include sweeteners (sugars and sugar substitutes), caffeine, vitamin supplements, amino acids, organic acids, and plant extracts. Because the analytes are already in solution, there is no need for extensive sample preparation. Dilution followed by direct injection into an HPLC is typically suitable. In this article we present two beverage applications using Ascentis Express HPLC columns. Ascentis Express columns offer faster HPLC on any system. One benefit is their ability to produce the resolution, efficiency, and speed on conventional HPLC systems that is associated with the use of sub-2 micron columns on a UHPLC system, without generating high backpressure. Column chemistries (RP-Amide and HILIC) were selected for this article based on their enhanced performance with polar compounds in comparison to C18.

By Merck KGaA, Darmstadt, Germany based in Darmstadt, GERMANY.

Herbicides are used throughout the world to combat the growth of unwanted plant life. These polar compounds are hydrophilic, so they may find their way into drinking water sources. While gas chromatography has historically been the preferred technique for analysis of herbicides in water samples, the use of LC-MS/MS for this application is gaining acceptance. This is due to the power of MS/MS to provide detailed identification of multiple analytes, but also in part due to the variety of HPLC stationary phases that are available. In particular, several HPLC phases are available that provide great retention and peak shapes for polar analytes, such as herbicides, even under mostly aqueous mobile phase conditions. The combination of these factors may possibly eliminate need for time-consuming sample preparation.

By Merck KGaA, Darmstadt, Germany based in Darmstadt, GERMANY.

Airborne aldehydes and ketones are collected by passing air through a cartridge containing 2,4-dinitrophenylhydrazine (DNPH). Carbonyl compounds react with the DNPH to form hydrazones, which are immobilized on the cartridge. These compounds can be easily eluted from the cartridge with acetonitrile and analyzed by HPLC with UV detection. Traditionally, this analysis including the workup contains a series of manual steps, which can become time-consuming and could incur experimental error. Automating the extraction of LpDNPH S10 cartridges and putting it in-line with the HPLC analysis will significantly reduce manual labor using this technique and this will improve reproducibility of the method by reducing potential experimental errors by the operator. The automation and unattended operation of the method leads to high throughput for determining airborne formaldehyde and acetaldehyde.

By Merck KGaA, Darmstadt, Germany based in Darmstadt, GERMANY.

An application was developed to demonstrate increased pigment removal for the analysis of pesticides, using Supel™ QuE Z-Sep/C18 QuEChERS and an Ascentis® Express C18 HPLC Column. The improved cleanup can decrease column and instrument fouling, leading to extended LC column lifetime and reduced instrument downtime.

By Merck KGaA, Darmstadt, Germany based in Darmstadt, GERMANY.

By ATN Engineering B.V. based in Stadskanaal, NETHERLANDS.

Challenged by computerized system validation. The consumer should have access to safe medications, medical devices and services through processes that are understood and controlled, and therefore reproducible. These claims are contained in healthcare regulations and laws worldwide.

By Mettler - Toledo Int. Inc based in Greifensee, SWITZERLAND.

Anyone and everyone who is responsible for operating and maintaining a swimming pool or spa has to test, monitor, and control complex, interdependent chemical factors that affect the quality of water bathers are immersed in. Additionally, aquatic facilities operators must be familiar with all laws, regulations, and guidelines governing what these parameters should be.

By Myron L Company based in Carlsbad, CALIFORNIA (USA).

Oxidation Reduction Potential or Redox is the activity or strength of oxidizers and reducers in relation to their concentration. Oxidizers accept electrons, reducers lose electrons. Examples of oxidizers are: chlorine, hydrogen peroxide, bromine, ozone, and chlorine dioxide. Examples of reducers are sodium sulfite, sodium bisulfate and hydrogen sulfide. Like acidity and alkalinity, the increase of one is at the expense of the other.

By Myron L Company based in Carlsbad, CALIFORNIA (USA).

Years ago, high purity water was used only in limited applications. Today, deionized (Dl) water has become an essential ingredient in hundreds of applications including: medical, laboratory, pharmaceutical, cosmetics, electronics manufacturing, food processing, plating, countless industrial processes, and even the final rinse at the local car wash.

By Myron L Company based in Carlsbad, CALIFORNIA (USA).

Contamination of circuit boards can bring about severe degradation of insulation resistance and dielectric strength. Cleanliness of completed circuit boards is, therefore, of vital interest. For those companies who have established circuit board cleaning procedures, the MIL Spec P-28809 has been used as a guideline for control. Now a simple `on line` test for the relative measurement of ionic contamination has been developed. This fast and economical method for testing circuit board cleanliness uses a Myron L Company Ultrameter II™ 4P or 6P, a suitable container, and a mixture of Dl (deionized) water and alcohol.

By Myron L Company based in Carlsbad, CALIFORNIA (USA).