PTR-MS systems for medical sector

PTR-MS are powerful tools for non-invasive, real-time breath gas analysis with many applications, such as screening for disease markers, study of pharmacokinetics or metabolic processes.

Real-time Breath Gas Analysis

Breath analysis - IONICON BETBreath gas analysis of volatile organic compounds (VOCs) has become a growing field of research in recent years, promising non-invasive with many potential applications such as screening for diseases biomarkers, monitoring of metabolic processes, pharmacokinetics, and drug testing. IONICON PTR-MS systems are particularly well suited for breath gas analysis: Their detection limits and linearity range match the concentrations typically found in breath. Beside offline analysis, where breath is collected in a container, their high sensitivity and fast response time allows to analyze breath directly and in real-time.

Real-Time Breath Analysis with PTR-MS

Real-time breath analysisIn real-time breath analysis, the exhaled breath is directly analyzed without sample preparation. Recording a complete breathing cycles, see figure, yields the concentrations for the end-tidal (alveolar) fraction and also the inspired (room-air) concentrations, which can be extracted by software. This provides immediate results and avoids complications from sample collection and storage. Also, the measurement of unstable compounds that undergo rapid degradation may only be possible by real-time analysis.

The medical research unit of IONICON (formerly IONIMED) has actively participated in several medical research projects. Our customers can benefit from this expertise which allows us to develop optimized products and to consult our clients for their medical application and scientific study design. IONICON has developed a BET breath-sampling inlet for real-time breath analysis with IONICON PTR-MS systems, which is certified for clinical use.