John Wiley & Sons, Ltd.

A NEW MEDIUM FOR CAENORHABDITIS ELEGANS TOXICOLOGY AND NANOTOXICOLOGY STUDIES, DESIGNED TO BETTER REFLECT NATURAL SOIL SOLUTION CONDITIONS

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A new toxicity test medium for C. elegans is presented. The test solution is designed so that it provides a better representation of natural soil pore water conditions than currently available test media. The medium has a composition that can readily be modified to allow for studies of the influences of a range of environmentally relevant parameters on nematode biology and toxicology. Tests conducted in the new medium confirmed that nematodes reproduction was possible at a range of solution pHs, offering the potential to conduct toxicity studies under a range of conditions. A test to establish silver nanoparticle and dissolved silver nitrate toxicity, a study type not feasible in M9 or agar media due to precipitation and nanoparticle agglomeration, indicated lower silver nanoparticle (EC50 6.5 mg Ag/L) than silver nitrate (EC50 0.28 mg Ag/L) toxicity. Characterisation identified stable nanoparticle behaviour in the new test medium. Environ. Toxicol. Chem. © 2013 SETAC

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