John Wiley & Sons, Ltd.

A toxicokinetic and toxicodynamic model approach of Myriophyllum spicatum to predict effects caused by short‐term exposure to a sulfonylurea

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Toxicokinetic and toxicodynamic models are a promising tool to address the effects of time‐variable chemical exposure. While standard toxicity tests rely, in most cases, on static concentrations, these chemical exposure patterns are unlikely to appear in the field, where time‐variable exposure of chemicals is typical. In this study, we integrated toxicodynamic processes into an existing model that includes toxicokinetics and growth of the aquatic plant Myriophyllum spicatum, to predict the impact on plant growth of two iofensulfuron short‐term exposure patterns. To establish a method that can be used with standard data from risk assessments, toxicodynamics of iofensulfuron are based on effect data from a 14‐day standard toxicity test using static concentrations. Modelling showed that the toxicokinetic and toxicodynamic growth model of M. spicatum can be successfully used to predict effects of short‐term iofensulfuron exposure by using effect data from a standard toxicity test. A general approach is presented, in which time‐variable chemical exposures can be evaluated more realistically without conducting additional toxicity studies. This article is protected by copyright. All rights reserved

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