John Wiley & Sons, Ltd.

Accumulation and effects of 90‐day oral exposure to dechlorane plus in quail (Coturnix coturnix)


While a number of studies have addressed bioaccumulation of the flame retardant Dechlorane Plus (DP), little information on the adverse effects of DP on animals, especially bird species, is available. In the present study, male common quails (Coturnix coturnix) were consecutively exposed to commercial DP‐25 by gavage for 90 days at 1, 10, and 100 mg/kg/d dosages. Concentrations of DP isomers in liver, muscle, and serum were determined after exposure. Liver enzyme activities involved in xenobiotic biotransformation processes and oxidative stress were measured, as well as the contents of glutathione and maleic dialdehyde. Results showed that DP was more prone to accumulate in the liver than in muscle and serum in all exposed groups. In tested tissues, syn‐DP dominated in the high exposed groups (10 and 100 mg/kg/d) whereas anti‐DP tended to accumulate in the low exposed group (1 mg/kg/d). The concentration ratio of anti‐DP to total DP (fanti values) in the examined tissues were close to commercial DP in the low exposed group; however, the fanti values were significantly decreased in the high exposed groups. The enzyme activity of 7‐pentoxyresorufin‐O‐demethylase (PROD) significantly decreased in all exposed groups compared to the control group, while activities of Erythromycin N‐demethylase (ERND) and antioxidant enzyme catalase significantly increased in high exposed groups. Results implied that DP exposure levels influenced isomeric compositions in organs, and DP exposure altered hepatic alkoxyresorufin O‐dealkylase (AROD) activities and contributed to the biological effects of DP. Environ. Toxicol. Chem. © 2013 SETAC

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