John Wiley & Sons, Ltd.

Acute and chronic effects of diphenhydramine and sertraline mixtures in Ceriodaphnia dubia

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Ceriodaphnia dubia were tested to evaluate the acute and chronic interactive effects of diphenhydramine and sertraline. Observed effects were compared to two reference toxicity models, the concentration addition model and the independent action model. Results indicate that the two drugs exhibit additive toxicity in C. dubia. In some cases, individually sublethal concentrations of the chemicals resulted in 100% mortality when combined, demonstrating the potentially severe impact of trace environmental contaminants. Environ Toxicol Chem © 2013 SETAC

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