The direct discharge of palm oil mill effluent (POME) wastewater causes serious environmental hazards due to its high chemical oxygen demand (COD) and biochemical oxygen demand. This paper proposes a new approach for integrated technology of ultrasonic membrane for a POME treatment. The paper evaluated the economic viability based on the changes of the new design of ultrasonic membrane anaerobic system (UMAS) when a POME introduces this approach. Six steady states were attained as a part of a kinetic study that considered concentration ranges of 13,800–22,600 mg/L for mixed liquor suspended solids and 10,400–17,350 mg/L for mixed liquor volatile suspended solids. Kinetic equations from Monod, Contois and Chen and Hashimoto were employed to describe the kinetics of POME treatment at organic loading rates ranging from 1 to 15 kg COD/m3/d. throughout the experiment, the removal efficiency of COD was from 92.8 to 98.3% with hydraulic retention time from 500.8 to 8.6 days. The growth yield coefficient, Y, was found to be 0.73 gVSS/g COD, the specific microorganism decay rate was 0.28 day–1 and the methane gas yield production rate was between 0.27 and 0.62 L/g COD/d.