Analysis of Voglibose in pharmace utical formulat ions by HPLC with post-column derivat izat ion

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Courtesy of Pickering Laboratories, Inc.

Voglibose is an Alpha-Glucosidase inhibitor widely used for the treatment of diabetes. Alpha-glucosidase inhibitors are agents that delay the glucose absorption at the intestinal level and thereby prevent sudden surge of glucose after a meal. Vogilbose is the safest and most effective drug of its class.

Since Vogibose has no UV chromophore, post-column derivatization is employed to produce a fluorescent derivative.
This abstract describes a very sensitive and robust analytical method for the analysis of Voglibose in pharmaceutical tablets. Simple sample preparation and fast analysis time allow for using this method in high throughput environments.

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