In order to create a tool to help hydrologists and authorities to have good understanding about occurrences in stream flow regime together with its variation in the future under the impact of climate change in the Vu Gia Thu Bon catchment, a deterministic distributed hydrological model has been developed and constructed. This model covers the major processes in the hydrologic cycle including rainfall, evapotranspiration, overland flow, unsaturated flow, groundwater flow, channel flow, and their interactions. The model is calibrated and validated against the daily data recorded at seven stations during 1991–2000 and 2001–2010, respectively. The quality of results is demonstrated by Nash–Sutcliffe and correlation coefficients that reach 0.82 and 0.92, respectively, in discharge comparison. With water levels, the obtained coefficients are lower but the quality of results still remains high; Nash–Sutcliffe and correlation coefficients reach 0.77 and 0.89, respectively, in the upstream part of the catchment. This analysis demonstrates the performance of the deterministic distributed modeling approach in simulating hydrological processes one more time; it also confirms the usefulness of this model with ungauged catchments or large catchments. Additionally, this analysis proves the role of multi-calibration in increasing the accuracy of hydrological models for large catchments.