Biohazards and other interferences complicate the employment of off-the-shelf asbestos in water methods by traditional TEM techniques. Laboratories must implement creative strategies to prepare and analyze these samples to produce meaningful analytical data. Laboratory and personnel safety have to be considered before sample handling. The interferences also greatly diminished any reasonable targets for a working detection limit. Consequently the development of analytical procedures that remove hazards and concentrate any suspect asbestos mineral have been developed. Formulated reference materials used in the QA process were also studied.