The Srepok watershed in the Central Highland of Vietnam plays an important role in the economic development of the region. Any harmful effects of climate change on natural resources may cause difficulties for social and economic development in this area. The present study aims to predict and evaluate changes of water resources in the Srepok watershed under the impact of climate change scenarios by using the soil and water assessment tool (SWAT) model. The study used observed weather data from 1990 to 2010 for the first period and climate change scenarios A1B and A2 from 2011 to 2039 for the second period and from 2040 to 2069 for the third period. According to the climate change scenarios of the studied watershed, future minimum and maximum daily average temperature will rise in all climate change scenarios and the amount of annual precipitation will fall in scenario A1B and go up in scenario A2. Based on the simulation results, the annual water discharge in scenario A1B decreased by 11.1% and 1.2% during the second and third periods, respectively, compared with the first. In scenario A2, annual water discharge increased by 2.4% during the second period but decreased by 1.8% during the third period.