Differences in radio-sensitivity and tumour susceptibility in various strains of mice are well recognised. Among several commonly used inbred mouse strains, BALB/c has been consistently found to be sensitive to the development of various types of radiation-induced tumours. To elucidate the role of host genetic factors in radiation responses and to identify candidate susceptibility genes, we compared expression profiles in the liver tissue of C57BL/6 and BALB/c mouse strains following low-dose ionising radiation (LDR) exposure using microarray experiments. The two mouse strains showed significant differences in their gene expression profiles in response to radiation exposure. The differences were mainly in MAP-kinase and ubiquitin mediated signal transduction pathways. Thirty seven genes were identified which showed contrasting expression pattern between the two strains. Thus, we propose that different genetic backgrounds of the two strains play an important role in the differential activation of the cascades of signal transduction processes in response to LDR.
- Inderscience Publishers
- Comparative analysis of gene expression profiles in BALB/c and ...
Italy - Cans, radiators and cables recycling - Case Study
Customer: TECNOMETAL S.r.l.Country: ItalyMachinery: LINE FOR CANS, RADIATORS AND CABLES’ RECYCLINGGuidetti line, composed by PMG1200 electric pre-shredder, magnetic overbelt, granulator 950, dosing conveyor with zig-zag, Turbo625/4 and separator Robi71, complete with anti-explosion filter 16000 m³, with production from 800 to 1200 kg/h, based on the material processed. Its versatility has no equal.
Comparison of ultraviolet light emitting diodes with traditional UV for greywater disinfection
The current technological status of ultraviolet light emitting diodes (UV-LEDs) has reached a point where small-scale ultraviolet (UV) water disinfection applications, that is, for greywater reuse appear increasingly promising. This study compares the germicidal and economical aspects of UV-LEDs with traditional UV. Pure cultures and environmental greywater samples were exposed to different radiation doses from both UV sources with the germicidal effect comparative at equivalent doses. The impact of particle size...
Sensitivity analysis of the modelled deposition of 137 Cs on the Japanese land following the ...
Dispersion of radioactive material released to the atmosphere from the Fukushima Daiichi Nuclear Power Plant accident in Japan was modelled to assist the French Government in effectively providing public health advice to its citizens in Japan. It required estimation of radiation doses based on realistic scenarios and atmospheric dispersion modelling. In this paper, sensitivity studies are conducted to measure the influence of several parameters on the predicted contaminated zone. Priority is given to ground...
Radiation dosage case study
The Oak Ridge Associated Universities (ORAU) Team Dose Reconstruction Project assists the US National Institute for Occupational Safety and Health by reconstructing the radiation doses received by workers at various Department of Energy and Atomic Weapons Employer facilities. This work involves personal interviews with claimants, retrieval and validation of individual monitoring data, documentation of exposure conditions in site profile documents, and preparation of individual dose reconstruction reports.ORAU...
210 Pb in marine salt consumed by the inhabitants of Recife, Brazil
210 Pb is widely distributed in the marine environment. The aim of this research, therefore, was to determine 210 Pb concentrations in marine salt consumed by the population of Recife and calculate the ingestion dose of 210 Pb due to marine salt consumption. The ion exchange resin method was used. The concentration of 210 Pb varied from 4 to 365 Bq kg –1 in fresh weight. The estimated ingestion dose of 210 Pb due to consumption of marine salt in the population of Recife was 1.2 Sv, at least three orders of...