John Wiley & Sons, Ltd.

Comparison of biodegradation performance of OECD test guideline 301C with those of other ready biodegradability tests

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The OECD Guidelines for the Testing of Chemicals lists seven types of tests for determining the biodegradability of chemical compounds (301A–F and 310). In this study, we compared the biodegradation performance of test guideline (TG) 301C, which is applied in Japan's Chemical Substances Control Law, with the performance of the other six RBTs listed in the guidelines. TG 301C specifies use of activated sludge precultured with synthetic sewage containing glucose and peptone (301C sludge) as a test inoculum; however, in the other RBTs, activated sludge from wastewater treatment plants (WWTP sludge) is frequently employed. Analysis based on percentage biodegradation and pass levels revealed that the biodegradation intensity of TG 301C is relatively weak compared to the intensities of RBTs using WWTP sludge, and the following chemical compounds are probably not biodegraded under TG 301C conditions: phosphorus compounds; secondary, tertiary, and quaternary amines; and branched quaternary carbon compounds. The relatively weak biodegradation intensity of TG 301C may be related to the markedly different activities of the 301C and WWTP sludges. These findings will be valuable for evaluating RBT data in relation to Japan's Chemical Substances Control Law. Environ Toxicol Chem © 2013 SETAC

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