John Wiley & Sons, Ltd.

Cumulative risk assessment: A European perspective on the state of the art and the necessary next steps forward

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The first Europe‐wide system for chemical assessment and management was introduced in 1967 with the Dangerous Substance Directive 67/548/EEC, which established a hazard‐based classification and labeling system for chemicals on the European market. Subsequent risk‐based regulatory frameworks comprised e.g. Directive 93/67/EEC and Regulation (EC) No 1488/94, the two predecessors of the REACH Regulation. The enactment of these and similar European‐wide Directives and Regulations for chemical risk assessment, management and mitigation resulted in a decrease of the concentrations of many classical toxicants found in European populations and ecosystems over the last decades, despite the continuous increase in chemical production and use. Integr Environ Assess Manag © 2013 SETAC

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