Keywords: soluble proteins, gold surfaces, self-assembled monolayers, scanning force microscopy, amperometric biosensors, redox proteins, bacterial cytoskeletal protein FtsZ, nanotechnology, Spain, self-organisation, nanodevices, solid substrates
Directed self-organisation of soluble proteins on surfaces
Incorporation of proteins on surfaces is a first step in the lengthy process of using active biological molecules in man-made nanodevices. There is therefore a strong motivation to develop strategies for organising active proteins on solid substrates and it is very desirable to take advantage of the principles of self-assembly. In the present work, I summarise two strategies to orient and selectively adsorb proteins on gold surfaces previously modified with specially designed self-assembled monolayers. I also report on the on-going research describing the aggregating properties of a bacterial cytoskeletal protein on a surface to illustrate nature's ability to direct the self-assembly of dynamic structures.