Keywords: DNA bank, Siberia, chemical workers, low dose irradiation, genetic basis, individual radiosensitivity, radiobiology, low radiation, Russia, cytogenetic analysis, blood samples, acute myocardial infarction, human genome, ionising radiation
DNA and radiobiological material bank of persons exposed to ionising radiation
The structure of the DNA and radiobiological material bank of the Seversk Biophysical Research Center is described. Workers of the Siberian Group of Chemical Enterprises (SGCE) and their relatives are the subjects of the storage. Cytogenetic analysis, including Gbanding, is being performed for the participants. Currently, the bank contains 700 DNA and blood samples of workers of SGCE, 123 DNA and blood samples of cancer cases, about 500 DNA samples of children from Seversk city, and 100 blood samples of SGCE workers who survived acute myocardial infarction. DNA and blood accumulation is still in progress, but by this time, it is ready for large scale scientific projects devoted to the study of the genetic basis of individual radiosensitivity and consequences of low dose irradiation effect on the human genome.