Mining cities have undergone the process of extensive exploitation, which always results in a series of water issues. Integrated water resource management is necessary in improving water supply, allocation and quality without damaging economic development. This article constructs a linear optimization model including a ‘Top-Down’ socio-economic mode, and ‘Bottom-Up’ water quality control and water supply–demand modes with integrated water resource management focused on water allocation and water reclamation. Based on computer simulation, the model can propose a water resource management under the constraints of water supply–demand and water quality control, and the model can precisely predict the influences of water resource management on economic development, water utilization and water quality. Taking Ordos, a Chinese national resource city, as a case study, this model addresses a detailed water resource management, including a water allocation plan among industries and water reclamation plan with technologies, selection, arrangement and subsidies. The implementation of water resource management can fulfill multiple objectives on water quantity, water quality and sustainable economic development. This study indicates that water resource management with a comprehensive dynamic model can be a maneuverable approach to realize the sustainable development of economic growth and water resource utilization, as well as formulate the regional development plan.