John Wiley & Sons, Ltd.

Ecotoxicological thresholds – practical application to an industrial inventory

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The concept of Thresholds of Toxicological Concern (TTC), as a potentially useful tool in environmental risk assessment has been applied to an inventory of a home and personal care products company to derive a series of chemical class based ecoTTC values. Cationic chemicals of various types show notably higher toxicity than other classes and should be treated separately. Despite this the ecoTTC for the full data set presented here is only slightly lower than that derived previously for chemicals causing toxicity via Verhaar mode of action 1‐3. Exclusion of cationic chemicals resulted in an ecoTTC value slightly higher than the MoA 1‐3 value. These observations indicate that such data sets contain few specifically acting chemicals. The applicability of threshold approaches in environmental risk assessment has been extended to include a limited number of inorganic/ organometallic chemicals, polymers and all classes of surfactants. The use of such ecoTTC values in conjunction with mode of action‐based QSARs will allow the efficient screening and prioritisation of large inventories of heterogeneous chemicals focussing resources on those chemicals that require additional information to better understand any potential risk. This article is protected by copyright. All rights reserved

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