Inderscience Publishers

Effect of nanoscale topography on fibronectin adsorption to sputter deposited calcium phosphate thin films

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Fibronectin (FN) adsorption to Calcium Phosphate (CaP) thin film surfaces with topographical features in the submicron to nanometre range has been investigated. CaP thin films have been produced by Radio-Frequency (RF) magnetron sputter deposition and a sputtered Titanium (Ti) interlayer was used to create substrates with nanoscale surface features. Detailed X-ray Photoelectron Spectroscopy (XPS) analysis of the FN ad-layers indicated differences in the nature of the adsorption on the main surface types. Binding studies revealed that the FN had a stronger affinity for the CaP on sputtered Ti. These data suggest that nanoscale topography can influence FN adsorption on CaP thin film surfaces.

Keywords: calcium phosphate, CaP, fibronectin adsorption, FN, protein adsorption, nanoscale topography, sputter deposition, thin films, nanomaterials, thin film surfaces

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