John Wiley & Sons, Ltd.

Effects of dietary exposure of polycyclic musk HHCB on the metamorphosis of Xenopus laevis

0
1,3,4,6,7,8‐hexahydro‐4,6,6,7,8,8‐hexamethylcyclopenta‐[ɣ]‐2‐benzopyrane (HHCB, galaxolide, CAS number 1222‐05‐5) is a synthetic musk used extensively as a fragrance in many consumer products and classified as an emerging pollutant. The ecotoxicological information available for HHCB addresses exposure via water, but this compound is frequently adsorbed into particulate matter. The goal of this study was to assess the effects of dietary exposure to several environmentally relevant HHCB concentrations adsorbed in food during Xenopus laevis metamorphosis. The study sought to determine if such exposure to this synthetic musk resulted in histological changes in the thyroid gland in conjunction with changes in development (staging, timing to metamorphosis), body weight and length. Developmental acceleration on day 14, together with hypertrophy of the thyroid follicular epithelium in tadpoles, suggested a possible agonistic effect of HHCB, which would have been compensated after metamorphosis by regulatory mechanisms to maintain homeostasis. Further research into the potential thyroid‐related mechanisms of action of HHCB should be conducted. This article is protected by copyright. All rights reserved

Customer comments

No comments were found for Effects of dietary exposure of polycyclic musk HHCB on the metamorphosis of Xenopus laevis. Be the first to comment!