John Wiley & Sons, Ltd.

Endocrine disrupting effect of the UV filter benzophenone‐3 in zebrafish, Danio rerio

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The chemical UV filter benzophenone‐3 (BP‐3) is suspected to be an endocrine disruptor based on results from in vitro and in vivo testing. However, studies including endpoints of endocrine adversity are lacking. The present study investigated the potential endocrine disrupting effects of BP‐3 in zebrafish (Danio rerio) in the Fish Sexual Development Test (OECD TG 234) and a 12 day adult male zebrafish study. In TG 234, exposure from 0 to 60 d post hatch caused a monotone dose dependent skewing of the phenotypic sex ratio towards less males and more female zebrafish (NOEC: 191 µg/L, LOEC: 388 µg/L). Besides, gonad maturation was affected in both female fish (NOEC 191 µg/L, LOEC 388 µg/L) and male fish (NOEC 388 µg/L, LOEC 470 µg/L). Exposure to BP‐3 did not affect the vitellogenin concentration in TG 234. After 12 d exposure of adult male zebrafish, a slight but yet significant increase in the vitellogenin concentration was observed at 268 µg/L but not at 63 µg/L and 437 µg/l BP‐3. Skewing of the sex ratio is a marker of an endocrine mediated mechanism as well as a marker of adversity and therefore the conclusion of the investigation is that BP‐3 is an endocrine disrupting chemical in accordance with the WHO definition. This article is protected by copyright. All rights reserved

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