Human Embryonic Stem Cell (hESC) Products Industry - 2017 Trends and Opportunities

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ReportsnReports.com adds report Opportunities in Human Embryonic Stem Cell (hESC) Products - Trends and Forecasts to 2017 to its store. Stem cells are primitive cells found in all multi-cellular organisms that are characterized by self-renewal and the capacity to differentiate into any mature cell type.

Categories of stem cells existed are:

  • Embryonic stem cells, derived from blastocysts
  • Post-natal stem cells, derived from newborn tissues
  • Adult stem cells, found in adult tissues – including hematopoietic stem cells, mesenchymal stem cells, neural stem cells, and more
  • Induced pluripotent stem cells, reprogrammed from adult cells
  • Cancer stem cells, which give rise to clonal populations of cells that form tumors or disperse in the body

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Embryonic stem cells are stem cells derived from the inner cell mass of a blastocyst, which is a stage reached four to five days post-fertilization. They are the most pluripotent of all stem cell types and can develop into over 200 different cell types of the human body. Human embryonic stem cells (hESCs) were first derived from mouse embryos in 1981 by Martin Evans and Matthew Kaufman, and independently by Gail R. Martin. In 1995, the first successful culturing of embryonic stem cells from non-human primates occurred at the University of Wisconsin-Madison. Another breakthrough followed at the University of Wisconsin-Madison in November 1998 when a group led by Dr. James Thomson developed a technique to isolate and grow hESCs derived from human blastocysts.

Market Segments

To facilitate research resulting from these advances, a large and diverse market has emerged for human embryonic stem cell products, platforms, and technologies. In total, the global sales of these items compose the hESC product marketplace. One thriving component of this marketplace is the segment of companies that sell hESC research products to scientists.

Large companies selling human embryonic stem cell research products include Life Technologies, BD Biosciences, Thermo Fisher Scientific, EMD Millipore, Sigma, Aldrich, Lonza, R&D Systems, and STEMCELL Technologies, as well as more than 60 other suppliers that range in size from multinational corporations to small specialty companies.

As of 2013, following product categories accounted for more than 85% of all global hESC research product sales:

  • Embryonic stem cell culture products
  • Embryonic stem cell lines
  • Antibodies to embryonic stem cell antigens
  • Bead-based embryonic stem cell separation systems
  • Embryonic stem cell protein purification and analysis tools
  • Tools for DNA and RNA-based characterization of embryonic stem cells
  • Embryonic stem cell specific growth factors and cytokines
  • Tools for embryonic stem cell gene regulation
  • Embryonic stem cell services and mechanisms for in vivo and in vitro stem cell tracking

Because of their plasticity and unlimited capacity for self-renewal, hESCs have been proposed for use in a wide range of pharmaceutical applications, including:

  • Drug target validation and testing
  • Toxicology testing
  • Tissue engineering
  • Cellular therapies
  • Personalized medicine
  • And more

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Market Characterization:

It is also crucial for companies involved in the hESC product marketplace to understand the funding environment which supports hESC research. Within the United States, the federal government is currently an important, although not dominant, source of funding for stem cell research. The reason is that U.S. states are spending almost as much as the federal government on stem cell research and are actually spending more than the federal government on human embryonic stem cell (hESC) research. Private sources also contribute a huge amount of funding to stem cell research, with analysis of recent large gifts summing to over $1.7 billion.

There is conclusive evidence that entering the hESC marketplace is financially worthwhile, there are complicating factors for companies that hope to enter the market. Specifically, human embryonic stem cell research is heavily encumbered by patents held by the University of Wisconsin's Wisconsin Alumni Research Foundation (WARF), which creates significant challenges for companies seeking to develop new products.

The following represent the basis of research and analysis:

  • Preliminary Research - Examination of studies that need further confirmation by the scientific community, using extensive secondary research.
  • Fill-gap Research - Selectively sampled and focused primary research as a fill-gap strategy.
  • Historic Analysis - Historic analysis of all end-user industries/markets, requiring technology and market evaluations, growth projections, and market size estimation of end-user markets.
  • Historic Supply Chain/Raw Materials Analysis - Comprehensive analysis of data for each primary market segment.
  • Data Consolidation - Merging historic end-user market data to yield consolidated primary market data.
  • Cross Linking - Primary market data (historic) is compared with resulting end-user consolidated market data and the variance in percentages between data sets is calculated by year.
  • Variance Determination - A median figure for each year with a tolerance range equal to twice the variance percentage is determined.
  • Projections - End-user markets are projected forward (typically 2013-17) based upon historic growth, technology and market trends, and primary research from the market place.
  • Variance Factorization - Consolidation of projected end-user market data to yield derived primary market data. The data is adjusted to the historic variance determinations, as above. The resulting data is further verified by confirmatory primary research.
  • Confirmatory Primary Research - Resulting data is presented from companies or individuals participating as research partners. Variations from derived data are adjusted to reflect primary research based consensus.
  • Electronically Based End-User Surveys - In addition to the methods described above, electronically based end-user surveys are utilized. Surveys are distributed to a comprehensive panel of academic and industry representatives working within the market segment of interest.

Market intelligence report contained broad range of sources, including:

  • Grant Funding Databases (NIH database, DoD database, and more)
  • Patent Databases (USPTO, WIPO)
  • Scientific Publication Databases (PubMed, Highwire Press, Google Scholar)
  • Product Launch Announcements (Trade Journals, Company Websites, PR News Feeds)
  • Financial Data (SEC Filings, Investor Relations Packets)
  • International Surveys (Electronically Distributed End-User Surveys)
  • And More

Scientist survey results of this report include:

  • Emerging trends within the hESC research sector
  • Insights into hESC product selection, purchasing decisions, and preferred providers
  • Crucial trends and unmet market needs within the hESC marketplace
  • “Tested Sentences” for selling to hESC scientists
  • Breakdown of the marketing methods used by industry participants
  • And much more

Key Findings Include:

  • Charts, Trends, and Metrics for the hESC Product Market
  • Trends for hESC Grants, Scientific Publications, and Patents
  • 5-Year Market Size Projections (2013-2017)
  • Profitable Opportunities for hESC Product and Technology Development
  • Consumer Behavioral Patterns and Preferred Providers
  • Preferred Species for ESC Research
  • Crucial Trends and Unmet Market Needs
  • Breakdown of the Marketing Methods Used by Industry Participants
  • “Tested Sentences” for Selling to hESC Scientists
  • End-User Survey of hESC Researchers (101 U.S. / 146 International)

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