For successfully operating a vertical flow constructed wetland, the uniform distribution of wastewater on the surface of the soil filter is essential. In research, however, this aspect is often overlooked. This study presents a methodology for assessing discharge uniformity from perforated pipe systems via hydraulic modeling. First, the requirements and conditions for the simulation of perforated pipe systems are investigated and the model basics are explained. Then the whole process of model build-up, calibration, application and analysis is presented and discussed. The modeling is done by the software EPANET and supported by pressure measurements in the pipe system of a small wetland treating domestic sewage. A crucial factor in the modeling process is the choice of loss coefficients in dividing junctions. Different approaches for calculating such coefficients are compared. Model calibration is undertaken via the multicriterion optimization algorithm NSGA-II. By calibrating two parameters, a reasonable goodness of fit with the measured pressure values was achieved. Model results show that distribution uniformity of the pipe system in question is poor. An outlook on potential applications of hydraulic modeling of perforated pipe systems in vertical flow constructed wetlands is given.