Inderscience Publishers

Immobilising of anti-HPV18 and E. coli O157:H7 antibodies on magnetic silica-coated Fe
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for early diagnosis of cervical cancer and diarrhoe

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This paper presents the synthesis and properties of magnetic silica-coated Fe
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nanoparticles. Uncoated Fe
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nanoparticles with an average diameter of 9-16 nm and saturation magnetisation of around 66 emu/g were first prepared by co-precipitation method. After being coated by SiO
2
using the sol-gel method, the diameters of the coated particles ranged from 29 nm to 230 nm and their corresponding saturation magnetisation was reduced to 29 emu/g. The magnetic coated nanoparticles were attached to the monoclonal antibodies of HPV18 and E. coli O157:H7. The TG/DTA analyses indicated that antibodies were attached to the magnetic nanoparticles. The obtained results revealed that magnetic SiO
2
-coated Fe
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nanoparticles can be a promising candidate for the diagnosis of cervical cancer at an early stage with high accuracy.

Keywords: magnetic nanoparticles, diagnostics, uterocervical cancer, E coli, monoclonal antibodies, escherichia coli, cervical cancer, diarrhoea, cancer diagnosis, sol-gel, nanotechnology

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3
O
4
for early diagnosis of cervical cancer and diarrhoe
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