Water resources in Egypt have become stressed due to changes in climate patterns. Egypt is characterized by two seasons, a mild, wet winter and a hot, dry summer. In recent years, many areas have become vulnerable to the impact of extreme climate events. The impact of these events on water supplies has become more pronounced. This study states that there is a tangible impact of extreme climate events upon both water resources quality and water supplies. The Nile river water turbidity was investigated as an operational indicator for the water treatment plants (WTPs). The results illustrated that an unprecedented increase in average turbidity of raw water in Upper Egypt (from 4 up to 110 NTU) led to a cut in water supplies for up to 100 hours in some areas. While in Alexandria the turbidity did affect WTP operation efficiency, safe water could still be produced. Cuts in water supply would have an impact on hygiene and make people prone to use unsafe water sources. These consequences stimulate water supply bodies to develop action plans to mitigate and/or avoid such potential impacts on public health. This study suggests proposed steps to develop an appropriate plan to face such extreme events.