Keywords: radiation risk, chemical carcinogens, tumour formation, mathematical modelling, urethane, irradiation, toxicity, cancer risk, low radiation
Interaction of radiative and nonradiative factors in the process of tumour formation
The evaluation of dose-effect dependencies in the case of pure irradiation, and evaluation of these dependencies after addition of carcinogen at different times after irradiation, yields information on the particularities of the process of tumour formation under the combined action of radiation and chemical carcinogens. This is the basis for the present work. The dose-time dependency of the frequency of the appearance of adenomas was studied at different times of addition of urethane after irradiation. It was shown that the frequency of tumours is determined both by the radiation dose and the time interval between irradiation and addition of the carcinogen. The data obtained make it possible to analyse the period of conservation of induced damage and the nonlinearity of the process of tumour formation under the combined action of radiation and toxic factors on the organism. The latter is to be taken into account when forecasting the radiation risk under ecological conditions. A mathematical model was constructed to describe the amount of damage recovered by a chemical promoter after a concrete time delay after irradiation.