John Wiley & Sons, Ltd.

Internal concentration as a better predictor of metal toxicity than the fractional coverage of metals on biotic ligand: Comparison of three modeling approaches

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Courtesy of John Wiley & Sons, Ltd.

Modeling toxicity of metal mixtures poses unique challenges to incorporate bioavailability and metal speciation in metal exposures. Three models (models I, II, and III) were compared in the present study to predict and interpret the toxicity exerted by binary‐metal mixtures to zebrafish larvae, with the assumptions of competitions between metals based on BLM and toxic potencies of individual metals. In addition, three models had been developed through substituting binding constants (fMBL) for internal metal concentrations (CM,int) to directly delineating single metal and mixture effects on mortality of zebrafish larvae. Results indicated that three developed models appeared to be much better (p < 0.01) than three previous models in assessing toxicity of different metal mixtures and showed 10‐20% predictive improvement for each metal combination, with toxic equivalency factor (TEF)‐based model II showing the best performance in quantifying metal mixture toxicity. The three developed models generally provided reasonable framework and descriptions of bioavailability and additive (or nearly additive) toxicity for a number of binary metal mixtures. This article is protected by copyright. All rights reserved

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