Inderscience Publishers

Ionising radiation or chemical utagen induced chromosome aberration in lymphocytes from epidemiological data at Vietnam

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Studies on epidemiology of chromosome aberration induced in human lymphocytes were conducted in 81 donors selected from five agricultural inhabitant populations. The abnormal frequencies of chromosome aberrations were detected in four of the five investigative groups that had not been controlled for any environmental toxic contamination before. The completed and complicated band of detected chromosome aberrations was a clear indicative evidence of a genetic toxicity that might exist in the environment. Almost all types of chromosomal aberrations are explained by Savage's classification and molecular studies of Revell, Sax, Chardwick, Leenhout. The serious chromosome aberrations detected in some cells were never observed in other researches, and some chromosome aberrations, unable to be explained by Savage's classification, need to be discussed. The data analysing the frequency, distribution and classification of chromosome aberrations corresponded to the hypothesis that the genetic toxic factor was a radiomimetic chemical agent.

Keywords: chromosome aberrations, chromatid aberration, epidemiology, ionising radiation, lymphocytes, chemical utagen, Vietnam, agricultural populations

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