John Wiley & Sons, Ltd.

Is received dose from ingested soil independent of soil PAH concentrations: Animal model results

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Polycyclic aromatic hydrocarbon (PAH) bioavailability from ingested soils will vary between soils; however, the nature of this variation is not well characterized. Here, we used the juvenile swine model to link external exposure to internal benzo[a]pyrene (BaP) and anthracene exposure following oral PAH ingestion of 27 different impacted site soils, soots, or spiked artificial soils. Internal exposure of BaP and anthracene, represented by area under the plasma‐time curve (AUC), did not relate to soil concentration in impacted site soils, but did relate in spiked artificial soil. Point of departure (POD) modeling identified soil PAH concentrations greater than 1,900 mg kg−1 as the point where AUC becomes proportional to external dose. BaP internal exposure below 1,900 mg kg−1 had an upper 95% confidence interval estimate of 33% of external exposure. Weak relationships between soil:simulated gastrointestinal fluid PAH partitioning and AUC values suggest that differences in internal PAH exposure between soils may not be dominated by differences in PAH partitioning. In our opinion, our data best supports exposure assessment assuming constant internal PAH exposure below soil concentrations of 1,900 mg kg−1. However, because constant internal exposure would challenge several existing paradigms, we suggest that a bioavailability estimate of 33% of the external exposure is likely a workable solution. This article is protected by copyright. All rights reserved

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