analytical HPLC Articles

  • Method Scaling in Preparative HPLC: Analytical Method & Preparative Method

    VOC:  “I tried to scale up my analytical HPLC method to prep and it didn’t work.” Andy:  This is one of the most common things we hear from chemists wanting to do preparative chromatography. We also hear the following question pretty often too: VOC:  “I have a good analytical HPLC method, how do I scale it to ...


    By Waters Corporation

  • Purification of natural products - Case Study

    “Due to its versatility, the PrepChrom C-700 is a valuable instrument in our natural product isolation based research group, where preparative techniques such as column chromatography, flash chromatography and preparative HPLC are used on a daily basis.” Customer name Prof. Dr. Timo Niedermeyer Company / Institution University of ...


    By BÜCHI Labortechnik AG

  • Comparison of simple ozonation and direct hydrogen peroxide processes in TNT removal from aqueous solution

    Oxidation of 2,4,6-trinitrotoluene (TNT) using simple ozonation and direct hydrogen peroxide was studied. An analytical method based on the HPLC (high performance liquid chromatography) system was used for TNT detection. The influence of parameters such as pH of the solution (3–10), initial TNT concentration (10–100 mg/L), dosage of ozone (0.2–1 g/hr), H2O2/TNT molar ratio (250–1,000), ...


    By IWA Publishing

  • An overview of post-column derivatization methods from a pharmaceutical applications perspective

    High performance liquid chromatography (HPLC) is the technique of choice for separating analytes pursuant to their detection, identification, quantification and/or purification. Most organic substances, and certainly the majority of pharmaceuticals, are polar, nonvolatile or thermally labile molecules that are amenable to HPLC separation. Moreover, the availability of a large variety of LC column ...


    By Pickering Laboratories, Inc.

  • Rapid raw material identification for formulation compounds using handheld Raman technology

    Ever since the European Medicines Agency (EMA) recommended that all pharmaceutical companies test every raw material that passes through their manufacturing facilities, this practice has attracted great interest in the nutraceuticals, food manufacturing, cosmetics, and agricultural industries, pushing them to strive for more rigorous and technology-oriented quality control standards. In recent ...


    By B&W Tek

  • A bridge with our customers - Prominence-i (i-Series) - Case Study

    Anthem Biosciences, which is ranked among the top 5 leading Contract Research Organisations (CROs) in India, is emerging as a global leader in the domain of Integrated Pharmaceuticals business. Anthem, which calls itself a Contract Research and Innovation Service Provider (CRISP), offers a whole gamut of services dedicated to enabling and sustaining global research efforts in the discovery of new ...

  • Developing equipment specific lockout/tagout procedures – Case Study

    Challenge: Antea®Group was contracted by one of the world’s largest chemical manufacturing organizations to provide equipment-specific lockout / tagout procedures at their largest Research and Develop facility in North America. The overall objective of the project was to evaluate the worker risks during maintenance and repair operations associated with laboratory ...


    By Antea Group - USA

  • Alternative Analysis of Formaldehyde-DNPH and Other Carbonyl-DNPH Derivatives by Capillary GC

    Alternative Analysis of Formaldehyde-DNPH and Other Carbonyl-DNPH Derivatives by Capillary GC -  GC analysis of 15 carbonyl-DNPH compounds has some advantages over the HPLC analyses described in US EPA and other environmental methods.  Determination of formaldehyde and 14 other carbonyls in air according to US Environmental Protection Agency Method TO11  and American Society for ...


    By MilliporeSigma

  • Matrix LIMS configured and implemented within 3 months case study

    Laboratory staff at Glatfelter have established an extremely close, ongoing working relationship with Autoscribe. This has allowed the design and implementation in just 3 months of a configured Matrix Gemini LIMS for the company's corporate analytical services group. Organisation Established since 1864, global paper supplier Glatfelter has expanded its product range from high-quality ...


    By Autoscribe Informatics

  • What is the pressure limit for my LC column?

    This is a question we get in Tech Services fairly often.  Unfortunately, we are not able to provide a published limit for every column that we produce, but here are a few of them that we have specified: For 3 and 5 um fully porous particle ...


    By Restek Corporation

  • Focus on Biosensors

    What are Biosensors? A biosensor is a device capable of detecting a certain substance or analyte with high specificity. Examples of such analytes are glucose, lactate, glutamine and glutamate. Most biosensors measure the concentration of an analyte in an aqueous solution, usually producing an electrical signal, which is proportional to the analyte’s concentration in its measuring ...

  • What is a Syringe Pump?

    A syringe pump is a type of infusion pump originally developed to help administer drugs to patients in a controlled manner. Early attempts to construct infusion pumps were made in the 19th century. However, the first infusion device was introduced in the 1950s to be used in chemotherapy. In the 1970s, the development of ambulatory infusion technology enabled the pumps to be used in research; ...


    By Chemyx Inc

  • Pinnacle PCX Carbamate Testing at Nebraska Health

    Beta Site Evaluation of the EPA Carbamate in Drinking Water Method 531.1 with Pickering Laboratories Pinnacle PCX Integrated LC/Post-Column Derivatization Instrument. The Nebraska DHHS Public Health Environmental Laboratory conducts environmental testing for the state of Nebraska. It employs mandated U.S. Environmental Protection Agency (EPA) methods for the determination of regulated substances ...


    By Pickering Laboratories, Inc.

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