A new application of exposure assessment aimed at improving insight into source attribution of human infectious diseases, i.e. estimation of the relative contribution of sources and transmission routes, is developed and explored. Human exposure, calculated as the mean number of Campylobacters ingested per person per day, is used as an indication of the relative importance of Campylobacter ...
This review presents epidemiologic evidence of adverse health effects associated with residential proximity to traffic. Of the 29 peer-reviewed studies that met the authors’ defined criteria, 25 reported statistically significant associations with at least one adverse health effect across a broad range of exposure metrics and diverse geographical locations. Specific pollutants contributing to the ...
REACH requires that environmental exposure assessments be performed for all uses of dangerous substances that are marketed in the European Union in quantities above 10 tons per year. The quantification of emissions to the environment is a key step in this process. This publication is the first to describe the derivation of release factors and guidance for estimating use rates for quantifying ...
The use of alternatives assessment to substitute hazardous chemicals with inherently safer options is gaining momentum worldwide as a legislative and corporate strategy to minimize consumer, occupational, and environmental risks. Engineered nanomaterials represent an interesting case for alternatives assessment approaches as they can be considered both emerging “chemicals” of concern, as well ...
Under the terms of the Clean Water Act, criteria for the protection of human health [Human Health Ambient Water Quality Criteria (HHWQC)] are traditionally derived using United States Environmental Protection Agency (USEPA)‐recommended equations that include parameters for exposure assessment. To derive “adequately protective” HHWQC, USEPA proposes the use of default values for these ...
Working in hot environments can produce a strain on workers that may lead to discomfort, loss in performance and productivity, heat illness and death. For this reason there has been much research into human responses to hot environments. Although knowledge is not complete, a great deal is known and can be integrated to allow the proposal of practical methods for designing and evaluating working ...
First‐tier regulatory exposure assessments for pesticides assume that pesticide sorption is instantaneous and fully reversible. In EU regulatory guidance, an increase in sorption over time (‘aged sorption’) can be considered at the higher tier to refine predicted environmental concentrations in groundwater. Research commissioned by the UK Chemicals Regulation Directorate (CRD), funded by ...
Next generation atmospheric models are required to provide a realistic assessment of different types of chronic and acute environmental conditions and forecast the consequences on population health. These tasks were usually carried out with epidemiological studies, which are not adequate to indicate health effects. Therefore, models should be capable to carry out hazard identification, ...
Uncertainty reflects ignorance associated with population traits (e.g. average exposure levels to a contaminant), with models used to predict risk (e.g. which statistical model is correct), and with a host of other considerations. Variability reflects an intrinsic property of a system (e.g. body mass indices possess a distribution across a population). The incorporation of uncertainty and ...
The Effect Of Diversity In People's Eating Habits There are thousands of foods available on the market, with thousands of brands and hundreds of potential hazards in the food chain. Where do you start? People eat different things on different days, and different people have very different eating habits, not least during holiday seasons. This is natural variability in people's habits and ...
The Oak Ridge Associated Universities (ORAU) Team Dose Reconstruction Project assists the US National Institute for Occupational Safety and Health by reconstructing the radiation doses received by workers at various Department of Energy and Atomic Weapons Employer facilities. This work involves personal interviews with claimants, retrieval and validation of individual monitoring data, ...
Using the MOBILEE methodology, we performed a detailed air quality assessment for three scenarios for the ring road around Antwerp, a major city in Belgium, using PM10 and NOx emission inventories for 2003 (reference) and 2015 (projected future situation), followed by an assessment of the exposure of the population living in the vicinity of the planned constructions. PM10 turned out to be the ...
Objective: To relate medical surveillance outcomes to uranium biomonitoring results in a group of depleted uranium (DU)-exposed, Gulf War I veterans. Methods: Thirty-two veterans of Gulf War I who were victims of ‘friendly fire’ involving DU weapons, in whom exposure assessment can accurately be measured, had urine uranium concentrations determined using ICP-MS technology. Clinical laboratory ...
Potential use of polar organic chemical integrative samplers (POCIS) for exposure assessment of munitions constituents (MC), including 2,4,6‐trinitrotoluene (TNT) and hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine (RDX), and their breakdown products (aminodinitrotoluenes [ADNTs], diaminonitrotoluenes [DANTs], and hexahydro‐1,3,5‐trinitroso‐1,3,5‐triazine [TNX]), was examined. Loss of MC from the ...
On February 9, 2017, Inside EPA quoted the Bergeson & Campbell P.C. (B&C®) memorandum, “TSCA: EPA Releases Proposed Chemical Risk Evaluation Process under New TSCA,” regarding how a weight of evidence (WoE) approach would impact U.S. Environmental Protection Agency (EPA) risk evaluations. And a Jan. 19 Bergeson & Campbell memorandum on the proposal says that while the ...
On February 7-9, 2017, a conference focused on new tools and approaches for nanomaterial safety assessment will be held in Malaga, Spain. The conference is jointly organized by five major Seventh Research Framework Program (FP7) projects: NANOSOLUTIONS, GUIDEnano, Sustainable Nanotechnologies (SUN), NanoMILE, and eNanoMapper. It will present the main results achieved in the course of the ...
Polycyclic aromatic hydrocarbon (PAH) bioavailability from ingested soils will vary between soils; however, the nature of this variation is not well characterized. Here, we used the juvenile swine model to link external exposure to internal benzo[a]pyrene (BaP) and anthracene exposure following oral PAH ingestion of 27 different impacted site soils, soots, or spiked artificial soils. Internal ...
Engineered nanomaterials (ENMs) possess novel properties making them attractive for application in a wide spectrum of fields. These novel properties are not accounted for in the environmental risk assessment methods REACH proposes in their guidance on environmental exposure estimation, although ENMs are already applied in a variety of consumer and industrial products. It is thus necessary to ...
Insecticides are mainly used in the home environment, and most of them are recognised to pose risks for the human health. In particular, pyrethroids are an insecticide category widely used in agriculture and households, and for industrial purposes to get protection from mosquitoes, cockroaches and other insects. In this study, both exposure and risk following the application of insecticides by ...
This paper deals with prospective and retrospective ecological risk assessment (ERA) procedures for pesticides in surface waters as performed under European legislation (Regulation 1107/2009/EC; Directive 2009/128/EC; Directive 2000/60/EC). Priorities to improve the aquatic risk assessment and management of pesticides are discussed on basis of the following five theses: The management of the ...