hplc technology Articles

  • Speciation of five arsenic compounds in urine by HPLC/ICP-MS

    High-performance liquid chromatography (HPLC) coupled to an ICP-MS has become an invaluable analytical tool for the determinations of trace levels of individual arsenic compounds (speciation). Speciation of arsenic is used to improve our knowledge of arsenic’s biochemical interactions and to evaluate toxicity risks. The toxicity and bioavailability of arsenic is highly dependent on form or ...


    By PerkinElmer, Inc.

  • ACQUITY Arc System: Transferring Validated HPLC Methods within USP Guidelines

    The thought of transferring established high performance liquid chromatography (HPLC) methods onto a another vendor’s LC, or a new platform like UHPLC/UPLC, may cause a bit of anxiety for those that may be unaware of how easy it can be. The reason that the topic of analytical method transfer induces so much angst is that for the transfer of an LC method to succeed, the method has to work as ...


    By Waters Corporation

  • Rapid raw material identification for formulation compounds using handheld Raman technology

    Ever since the European Medicines Agency (EMA) recommended that all pharmaceutical companies test every raw material that passes through their manufacturing facilities, this practice has attracted great interest in the nutraceuticals, food manufacturing, cosmetics, and agricultural industries, pushing them to strive for more rigorous and technology-oriented quality control standards. In recent ...


    By B&W Tek

  • The development of cation-exchange chromatography in free amino acids analysis

    Although it was not called a liquid chromatograph, the first such instrument was introduced in late 1959 by Beckman Instruments and was designated the M.S. Amino Acid Analyzer in honour of Moore and Stein. Inject valves had yet to be invented, the buffer switching valves were glass stopcocks and the column temperature was controlled by circulating water baths. Two positive displacement pumps ...


    By Pickering Laboratories, Inc.

  • Chromatography Tips

    No.1 Gas Chromatography Tips  Our Founders and engineers of the company had accumulated more than 60 years experience in the research and development of HPLC instrumentation; HPLC column technology; mass spectrometer installation, training and services; chemical and biochemical separation, detection and quantification, Proteomics and cancer biomarker research and ...


    By AcuTech Scientific Inc.

  • A bridge with our customers - Prominence-i (i-Series) - Case Study

    Anthem Biosciences, which is ranked among the top 5 leading Contract Research Organisations (CROs) in India, is emerging as a global leader in the domain of Integrated Pharmaceuticals business. Anthem, which calls itself a Contract Research and Innovation Service Provider (CRISP), offers a whole gamut of services dedicated to enabling and sustaining global research efforts in the discovery of new ...

  • News on Air 2013, Volume 1: Products for Sampling

    For decades, Sigma-Aldrich has been a key supplier of innovative & high technology air monitoring products for various areas of gas/air sampling. Enclosed, you will find an overview on new and interesting devices to improve or simplify your air sampling. Supelco and Sigma-Aldrich offer a range of active and passive air sampling products, in addition to various analytical chemistry tools ...


    By Sigma-Aldrich Co., LLC

  • Out with the old, in with the new…

    We’re all familiar with the adage, “Out with the old, in with the new,” but we probably tend to think of it as it applies to clothes for donation or past relationships, and maybe not in terms of updating our old laboratory equipment. After attending my first WCBP conference, held in Washington, D.C. during January, and hearing life cycle management and ICH Q12 being discussed ...


    By Waters Corporation

  • Simon Fraser University Opens Suite of Mass Spectrometers for Natural Products Discovery Research

    As a graduate student at the University of British Columbia, Dr. Roger Linington discovered his future life’s work serendipitously. While studying sponges, it became clear to him that one of the challenges in studying macroorganisms is their limited or slowly replenishing supply. To perform mechanism and mode-of-action studies, he needed a larger, more accessible source of ...


    By Waters Corporation

  • Precellys application focus forensic - case study

    Forensic laboratories working with hard samples such as hair [1, 2J, bone [3], teeth, skin, etc. experience difficulties with DNA extraction due to the high energy needed to grind these tissues. Moreover, biological evidence is available in small quantities and the current techniques used do not provide high quality results. The Precellys homogenizers provides high speed sample disruption based ...

  • The Advantages of a Targeted 2D LC Approach

    Webinar Highlights | Focus on the Relevant: The Advantages of a Targeted 2D Chromatography Approach Hi folks, I’m Daniel Root, Senior Product Marketing Manager for Multidimensional LC Systems at Waters. I recently conducted a webinar that addressed multidimensional liquid chromatography – an exceptional tool for the improvement of characterization and separation of ...


    By Waters Corporation

  • High-throughput Microscale Bioanalysis is not a Paradox

    Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in our group knows how to use it!” Maybe even, “there’s no way I can successfully transfer that method, so why ...


    By Waters Corporation

  • Toxicity Identification Evaluation (TIE) as a Tool for Water Quality Management

    Whole effluent toxicity (WET) testing has evolved into a critical element of many National Pollutant Discharge Elimination System (NPDES) permits issued to both industrial and municipal dischargers. Over 6,500 dischargers to both fresh and salt waters are required to conduct toxicity tests to determine if their effluent might be potentially toxic to organisms in the receiving system. While ...


    By AECOM

  • Thermo Scientific connects at GPSG Brazil delivers enterprise-level productivity linking laboratories to ERP - case study

    The Global Pharmaceutical Supply Group (GPSG) Brazil is an APILA unit of Janssen-Cilag Farmacêutica Ltda., (www.janssen-cilag.com.br) located in São Paulo, Brazil. Janssen-Cilag is one of the world’s leading research-based pharmaceutical companies specializing in pain management and fungal disease. Janssen-Cilag is a member of the Johnson & Johnson family of companies; the ...

  • Better tools for fast and convenient Patulin analysis

    Analytical Standards and New SupelMIP SPE Cartridges The mycotoxin patulin is often found in rotten apples. It is mostly produced by Aspergillus, Penicillium and Byssochlamys and shows a variety of short-term and long-term effects in animal studies, ranging from gastrointestinal problems and neurotoxicity to genotoxicity and teratogenicity. Therefore, many countries set limits for patulin ...


    By Sigma-Aldrich Co., LLC

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