LC-MS Articles
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LC/MS/MS Analysis of Mycotoxins
Mycotoxins are fungal poisons that threaten the world food supply. Regulatory agencies have imposed limits on levels of mycotoxins allowed in food. Food safety is ensured by testing for the presence of mycotoxins by methods such as LC-MS-MS. In addition to mycotoxins, many other known and unknown chemicals threaten the food supply, however their presence might be missed by LC-MS-MS methods which ...
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WRIB 2016: “Diversity of Platforms and Approaches Needed for Bioanalysts”
Held April 18–22 in Lake Buena Vista, Florida, WRIB 2016 was well attended this year, with about 700 attendees. This 10th Workshop on Recent Issues in Bioanalysis, where regulators and professionals representing pharma/biopharma, biotech, CRO organizations gather to discuss challenges in method development and emerging approaches, proved as fruitful as years past. Here are a few high-level ...
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Quantitative Analysis of ADC Components - Ligand Binding Assay (LBA) and LC-MS/MS
There are both large and small ADC molecules. A variety of biological analysis methods and platforms are needed to analyze the diversity of ADCs. Conventional LC-MS/MS small-molecule assays are often used to analyze uncoupled payloads and DAR distributions over time, while ligand binding assays (LBA) and LC-MS/MS can also be used to analyze total antibodies (TAb) and total ADCs. The choice of ...
By BOC Sciences
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Analysis of Isocyanates using the ASSET EZ4-NCO Dry Sampler
Introduction Isocyanates are used as a raw material to produce a number of products such as automotive paints, rigid and spray foam insulation, and furniture. Personal exposure can occur while the products made with isocyanates are being applied, or when the materials are removed by grinding or thermal degradation. Workers who are exposed to these compounds are at risk for respiratory disorders ...
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Aston University removes the hassle from their gas supply with the Infinity NM32L - Case Study
Aston University, a research-led University known for its world-class teaching quality and strong links to industry, government and commerce, are using one of Peak's Infinity NM32L nitrogen generators for their LC-MS. Name: Husam Sheena Job Title: Research Fellow Company: Aston University, Birmingham, UK Aston University Aston University, a research-focused university in Birmigham, ...
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Scientific Police Institute (France) - Case Study
Name: Grégory Deffontaine Job Title: Engineer Company: Scientific Police Institute (France) Gregory Deffontaine, Engineer, Scientific Police Institute Peak’s gas generators are built to last Gregory Deffontaine works as an Engineer for the French Scientific Police Institute and is using an NM30LA nitrogen gas generator to run his LC-MS application. In this user story he ...
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Genius XE -What does XE mean?
Genius XE Nitrogen provides a premium standalone nitrogen solution for high performance LC-MS. Inspired by the success of our best-selling Genius line of nitrogen gas generators for LC-MS, Genius XE Nitrogen is a cutting-edge evolution combining advanced technology with refined and robust engineering. You can learn why the Genius series was named 'Genius' here. To find out why Genius XE Nitrogen ...
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Comparison of
Microcystis aeruginosa (PCC7820 and PCC7806) growth and intracellular microcystins content determined by liquid chromatography–mass spectrometry, enzyme-linked immunosorbent assay anti-Adda and phosphatase bioassayCyanobacteria are able to produce several metabolites that have toxic effects on humans and animals. Among these cyanotoxins, the hepatotoxic microcystins (MC) occur frequently. The intracellular MC content produced by two strains of Microcystis aeruginosa, PCC7806 and PCC7820, and its production kinetics during the culture time were studied in order to elucidate the conditions that favour the ...
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Identifying rAAV Residual Impurities with LC-MS - Case Study
Gene therapies involving recombinant adeno-associated viral (rAAV) vectors have been approved by FDA, EMA, and used in well over 100 clinical trials, demonstrating efficacy against many genetic diseases. Improvements to AAV production and purification processes have focused on improving gene delivery safety profiles by removing process impurities, fulfilling current good manufacturing practices ...
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Bios Analytique - Case Study
Name: David Augustus Job title: Sales Manager Company: Bios Analytique Bios Analytique are a leading European company specializing in the rental and leasing of Life Sciences & Chemical Analysis equipment. They are official partners of Agilent Technologies, world leaders in life sciences, diagnostics and applied chemicals markets and an official distributor of Peak Scientific laboratory ...
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Microflow LC offers better sensitivity due to reduced matrix effects!
What is matrix effect? In my last post, What is Microflow, I talked about two main parameters, better sampling efficiency and reduced matrix effect, for microflow LC/MS offering higher sensitivity than its conventional counterpart. Let’s take a close look at the matrix effect. It is a result of co-eluting components, usually the material in the sample other than the analytes or the ...
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Genius XE generators are first to be equipped with our patented ECO technology
When only exceptional will do, you need exceptional technology. Designed to generate nitrogen gas for LC-MS/MS and other laboratory instruments which require analytical grade nitrogen, Genius XE is our most advanced nitrogen gas generator yet. To provide ever more advanced and sophisticated analytical instruments with the quality nitrogen gas supply that they require, we designed Genius XE as a ...
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Genius NM32LA solves problems for Bispebjerg Hospital - Case Study
Bispebjerg Hospital is a hospital in Denmark which forms part of the Copenhagen University Hospital. Built in 1913, the hospital has grown into a large modern city hospital and it has many different specialities, including Dermatological research. Name: Peter Olsen Job Title: Pharmacist/Analytical Chemist Company: Bispebjerg Hospital, Copenhagen, Denmark. Department of Dermatological Research ...
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NM32LA helps provide a consistent Nitrogen supply - Case Study
In this user story, North Carolina State University describes the benefits they received from switching from tanks to a Peak Scientific NM32LA nitrogen gas generator. Company: North Carolina State University Job Title: Senior Researcher North Carolina State University uses a Peak Scientific Genius NM32LA gas generator to provide a consistent flow and purity of nitrogen gas to their Waters ...
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The possible reduction pathways of 2,4,6-trinitrotoluene (TNT) by sulfide under simulated anaerobic conditions
To predict the final fate of 2,4,6-trinitrotoluene (TNT) and its intermediates in an anaerobic fermentative solution containing reduced sulfur species and to provide a basis for the adoption of remediation methods, we investigated the pathways of TNT (TNT0 = 50 mg/L) reduction by Na2S at 30 ± 1 °C in an acetic acid–sodium bicarbonate buffer. Liquid chromatography/mass spectrometry (LC/MS) was ...
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MVZ Labor Dr. Fenner & Kollegen - Case Study
Name: Anja Krüger Job Title: Clinical Toxicology Coordinator Company: MVZ Labor Dr. Fenner & Kollegen Anja Krüger with her Waters XEVO and Genius NM32LA Reliability a bonus for toxicology lab The research Anja Krüger, Clinical Toxicology Coordinator, and her colleagues at the MVZ Lab in Hamburg, Germany, carry out is focused on human medical diagnostics aiming to ...
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Quantitative Analysis of Pyrethroids in Soil and Sediment Using Triple Quad LC-MS/MS
Pyrethroid pesticides are used widely around the world as agricultural and household insecticides. Synthetic pyrethroids are slightly soluble in water and easily adsorbed in soil. In recent years, pyrethroid residues have been confirmed in soil and sediment in both agricultural and urban areas. Pyrethroids, while posing little danger to humans, exhibit a high toxicity to aquatic organisms and ...
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National University of Singapore User Story - Case Study
NUS is a research intensive university and has many profound areas of research interests and excellence; ranging from biomedical sciences and humanity to science and engineering. In this User Story from the university, Dr Sam discusses his use of a Peak nitrogen generator to support his application and why he is satisfied with the [Peak Protected] Service Plan. Name: Dr Pondy Murugappan ...
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7 steps to changing carrier gas from helium to hydrogen
Peak Scientific have released a new article which can be found in the Learn section of their website. The article titled, "7 steps to changing carrier gas from helium to hydrogen" is Dr Ed Connor’s latest application note which focuses on what is required for a lab to change its gas supply from helium to hydrogen and the benefits of making the switch. Going through the 7 steps will give ...
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News on Air 2013, Volume 2: Products for Separation
Supelco® has developed the most extensive line of special purpose columns designed for industry specific applications; including environmental and industrial hygiene. These columns are manufactured to deliver high resolution, great analyte response, low bleed and long column life; allowing analysts to achieve the analytical performance they require. In this issue, you will find easy-to-read ...
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