lc/ms Articles

  • Analysis of TNT, RDX, and CL-20 by APCI LC/MS/MS

    IntroductionThe detection and characterization of explosives has gained the interest of various analytical laboratories and researchgroups around the world.For the forensic community, trace analysis of explosive residues after arson and terrorism is of critical interest.Biologists and environmentalists monitor biotransformation of these high energy compounds when evaluating ...


  • Analysis of Nitrofurans Metabolites by Positive Ion Electrospray LC/MS/MS

    IntroductionNitrofuran antibiotics are veterinary drugs. The use of these in food production is already banned in the United States,Australia, Canada, Japan, Singapore, Bangladesh, and the European Union because of a possible increased cancer-riskthrough long-term consumption.Trace amounts of nitrofurans contamination has been found in warm-water prawns, shrimp, and chicken. ...


  • Analysis of PFCs in Environmental Water Using Triple Quadrupole LC/MS/MS

    Organofluorine compounds such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) are highly stable chemical compounds which are widely used as water repellents, oil repellents and coating agents. These compounds do not decompose easily in the natural world due to their stability. Reports of their detection in rivers, streams, tap water, food, as well as in the atmosphere ...

  • LC-MS/MS Method for Evaluation of PPCPs in Environmental Water

    Pharmaceutical and personal care products (PPCPs) encompass a family of compounds used by individuals for health and cosmetic purposes, as well as compounds used by the agricultural industry to maintain health of livestock. The number of individuals who are using these products is increasing which has caused an increase in environmental detection. The effect on humans and the environment is still ...

  • Quantitative LC-MS/MS Analysis of Microcystin Cyclopeptides: EPA Method 544

    Accurate and sensitive characterization and quantification of a structurally diverse class of microcystin cyclopeptides was accomplished using UHPLC-MS-MS. In this analysis, microcystins-RR, YR, and LR were measured using a Nexera UHPLC with a LCMS-8050 triple quadrupole MS detector with ESI ionization in accordance with EPA Method 544. The results of this study ...

  • High Throughput LC-MS-MS Analysis of Carbendazim in Orange Juice

    Highly sensitive analytical methods are necessary to prevent contaminated produce from entering the food supply. In order to help move fresh imports through customs without delay, methods must be rapid and cost effective, in order to test imports thoroughly. LC-MS offers the highly sensitive, robust measurement needed, while ultra high performance liquid chromatography enables high speed ...

  • Analysis of Haloacetic Acids in Tap Water Using LC/MS/MS

    Haloacetic acids are produced as by-products of chlorination in the water treatment purification process. Three haloacetic acids, monochloroacetic acid (MCAA), dichloroacetic acid (DCAA), and trichloroacetic acid (TCAA), are subject to water quality standard for drinking water with established limits (MCAA: 0.02 mg/L, DCAA: 0.04 mg/L, TCAA: 0.2 mg/L) by Japan Ministry of Health, Labour and ...

  • Analysis of Pesticides in Foods Using Triple Quadrupole LC/MS/MS

    Pesticides are widely used in agricultural products to protect crops from insect infestation during cultivation and product transport. With the heightened concern for food safety, “Positive List System was introduced in Japan on May 29, 2006. These limits ban the sale of food containing pesticides that exceed specified concentrations to ensure the safety of food circulating in the market. ...

  • 2.1 mm ID micro carbamates column ideal for LC-MS confirmation

    Post-column derivatization of carbamates with hydroxide and OPA is the method of choice for the detection of carbamates because of its high selectivity and high sensitivity (US EPA 531.1 & AOAC 985.23).  To confirm the finding of carbamates in the tested samples, there are various possibilitites: To confirm the finding of carbamates in the tested samples, there are various ...


    By Pickering Laboratories, Inc.

  • Is Microflow LC a Reality or Perception?

    Microflow or nanoflow chromatography has been used mostly in the academic and fundamental research environment in the past for its various advantages over analytical liquid chromatography, but rarely in the industrial settings. This is most likely because many of us believe it is a pain-in-the-neck technique to perform! But is this a reality or just a ...


    By Waters Corporation

  • Cylindrospermopsin determination in water by LC‐MS/MS: Optimization and validation of the method and application to real samples

    A new method for determining dissolved cylindrospermopsin (CYN) in waters using solid‐phase extraction (SPE) with graphitized carbon cartridges and quantification by liquid chromatography coupled with tandem mass spectrometry (LC‐MS/MS) is described and discussed. The method has been suitably validated: the linear range covered is from 0.900 to 125 µg CYN/L. Limits of detection and quantification ...


    By John Wiley & Sons, Ltd.

  • Quantitative Analysis of Pyrethroids in Soil and Sediment Using Triple Quad LC-MS/MS

    Pyrethroid pesticides are used widely around the world as agricultural and household insecticides. Synthetic pyrethroids are slightly soluble in water and easily adsorbed in soil. In recent years, pyrethroid residues have been confirmed in soil and sediment in both agricultural and urban areas. Pyrethroids, while posing little danger to humans, exhibit a high toxicity to aquatic organisms and ...

  • Application of a GPC-LC-MS/MS method for the determination of 31 mycotoxins in edible oils

    Gel Permeation Chromatography (GPC) is widely used for sample clean up in mycotoxin analysis. The most commonly described methods use GPC columns packed with SX-3 BioBeads suitable for cleaning Zearalenone, Aflatoxins and Trichothesenes from edible oils and fatty matrices. Separation of Fumonisins from the oil fraction are inadequate with this column. The new GPC column designed by LCTech shows ...


    By Pickering Laboratories, Inc.

  • Analysis of Non-Volatile Pesticide Residue in Vegetables by Positive/Negative ESI LC/MS/MS

    IntroductionPesticide residue analysis in vegetables has increased dramatically in recent years due to the quality improvement in theagricultural production (1,2) and governmental monitoring of food safety (3).In Almería, the largest agricultural region in Spain, it is very important to determine the maximum number of residues inthe highest number of samples per day. Fast, highly selective and ...


  • A Simple and Ultra-Sensitive LC/MS/MS Method for Analysis of N-Methyl Carbamates in Water

    IntroductionN-methyl carbamate pesticides are widely used due to their broad range of activity. Water sources can be polluted bycarbamates through surface water runoff from areas such as agriculture fields, golf courses, and residential properties.Human and animal studies have suggested that long-term, low-level exposure to carbamates can cause adverse healtheffects, including ...


  • LC/MS/MS analysis of metabolites of synthetic Cannabinoids JWH-018 and JWH-073 in Urine

    Abstract A liquid chromatographic method was developed to resolve a comprehensive set of metabolites of JWH-018 and JWH-073. In addition to the chromatographic analysis method, an extraction method was developed to recover a broad range of synthetic cannabinoid metabolites, including carboxylic acid metabolites that are not traditionally recovered using a high pH liquid/liquid extraction. ...


    By Restek Corporation

  • Analysis of Phenolic Estrogen Mimics in River Water by Negative Ion Electrospray LC/MS/MS

    IntroductionBisphenol A (BPA) is a primary raw material used for the production of polyacrylates, epoxy resin, phenolic resin, andpolycarbonate plastic. 4-Nonylphenol (4-NP) is a degradation product of alkylphenol ethoxylate detergents used inhousehold and industrial cleaning products. Alkylphenol ethoxylate is also widely used as an additive in plastics thatare used for food ...


  • Rapid Quantification of Perfluorinated Compounds in Drinking and Surface Water Using LC-MS/MS

    As contaminants of emerging concern, research on PFCs is ongoing to determine the impacts of these materials on human health and the environment. A CDC study detected four of these analytes in >98% of serum samples representative of the general US population above age twelve. Low level analysis of these compounds is challenging due to their ubiquitous presence in the laboratory and analytical ...

  • Fast LC-MS-MS Quantitation of N-Methyl Carbamate Pesticides in Food using Bond Elut® Plexa™ and Pursuit® XRs C18

    A fast quantitation method for the analysis of N-Methyl Carbamate pesticide residues in vegetables and grains has been developed with Bond Elut Plexa clean-up, Pursuit XRs C18 columns, and 320 LC-MSMS. High recoveries were obtained for most carbamates screened in all matrices tested at 1 ppb levels. Good linearity of the calibrationcurves was observed for all analytes, over the range from 1 ppb ...


  • Fast LC/MS/MS Quantitation of N-Methyl Carbamate Pesticides in Food Using Bond Elut™ Plexa™ and Pursuit™ XRs C18

    AbstractA fast quantitation method for the analysis of N-methylcarbamate pesticide residues in vegetables and grainshas been developed with Bond Elut Plexa clean-up, Pursuit XRs C18 columns, and 320-MS LC/MS/MS. Highrecoveries were obtained for most carbamates screened in all matrices tested at 1 ppb levels. Good linearity of thecalibration curves was observed for all analytes, over ...


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