LC/MS Articles
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Adelaide Proteomics Centre - research across human diseases with Genius XE 35 - Case Study
To support their analyses, the team at APC have chosen Peak’s Genius XE 35 to supply gas to their Bruker TimsTOF Pro. The Adelaide Proteomics Centre (APC), part of the University of Adelaide (UoA), Australia, is renowned for its state-of-the-art facility for scientists conducting specialized research in proteomics, where the team at APC offers dedicated services in mass-spectrometry based ...
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Chromatography explains why luminous fungi glow in the dark
When you think of organisms that glow in the dark you might think of jellyfish or fireflies, but some mushrooms glow after dark too, and now we know how. A team of international researchers from Russia, Brazil and Japan were able to identify the chemical reactions employed by fungi to make them glow and they discovered that their glow is due to a compound called oxyluciferin. The compound is ...
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High-throughput Microscale Bioanalysis is not a Paradox
Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in our group knows how to use it!” Maybe even, “there’s no way I can successfully transfer that method, so why ...
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Application of LC-MS in the Bioassay of Oligonucleotide Drugs
Introduction of oligonucleotide drugs Oligonucleotides are a class of nucleic acid molecules consisting of dozens of nucleotides with short sequences. They mainly inhibit the expression of target proteins through gene silencing so as to achieve the purpose of treating diseases. The world's first antisense nucleic acid drug was approved in 1998, which started the journey of oligonucleotide drug ...
By BOC Sciences
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UCT XtrackT® Sorbent Cited in Drugs in Wastewater Article
Environmental analysts are often tasked with the evaluation of illicit and prescription drugs in wastewater samples in an attempt to better understand the epidemiology of a populated area. Due to the challenging consistency of this matrix, clean-up is often vital in order to achieve accurate detection. In a recent paper authored by Richard Bade et al., published in Analytical and Bioanalytical ...
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Trinity College Dublin - Case Study
Name: Dr Gary Hessman Job title: Technical Officer Company: Trinity College Dublin Dr Gary Hessman works as Technical Officer for Trinity College Dublin where he assists the College in its LC-MS research. The College is very diverse covering a range of sample types and therefore the equipment Gary and his students use must be fit for purpose, durable and ready to go at the ‘push of a ...
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Quantitative LC-MS/MS Analysis of Microcystin Cyclopeptides: EPA Method 544
Accurate and sensitive characterization and quantification of a structurally diverse class of microcystin cyclopeptides was accomplished using UHPLC-MS-MS. In this analysis, microcystins-RR, YR, and LR were measured using a Nexera UHPLC with a LCMS-8050 triple quadrupole MS detector with ESI ionization in accordance with EPA Method 544. The results of this study show that the Shimadzu platform ...
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What should you know before you buy nitrogen gas?
Modern laboratories use a number of gases for various research purposes. One gas which is commonly used in labs is nitrogen. This blog will explain why laboratories use nitrogen and the various ways in which it can be purchased, such as via nitrogen generators and cylinders. Why do laboratories use nitrogen gas? Nitrogen is an inert gas which means that it has low reactivity with other ...
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Mayne Pharma: Lab productivity increased with Peak nitrogen generator - Case Study
How to increase your productivity Increased with Peak Nitrogen Generator With over 30 years of success in developing new oral drug delivery systems, Mayne Pharma commercializes a wide variety of pharmaceutical products across the globe. With a facility in Greenville, North Carolina, Mayne Pharma specialize in the complex dosage of potent compounds and controlled substances. Name: Shawn ...
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Mass Spectrometry Makes Cents for UC San Diego Clinical Laboratory
“Fast is fine; but accuracy is everything.” The quote is attributed to the famous Wyatt Earp, a sharpshooter and lawman who, with help from his two brothers, sent three outlaws to their graves in the Gunfight at the O.K. Corral in Tombstone, Arizona in 1881. One hundred and twenty five years later, Dr. Rob Fitzgerald of the University of California, San Diego, (UC San Diego) School ...
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Nitrogen Generators in Germany
Need a nitrogen generator for your laboratory in Germany? Whether you are in Berlin, Munich or anywhere else in Germany, Peak Scientific nitrogen gas generators, backed by local service and support, are used by labs all over the globe. Read on to learn more. Laboratory applications which require nitrogen gas, such as LC-MS and ELSD, require a reliable gas supply to produce reliable results. Many ...
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Beneficial Effects of Akkermansia muciniphila are not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPAR Agonists.
Abstract: Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in the context of obesity and associated metabolic disorders. Although a first proof-of-concept of its ben eficial effects has been established in the context of metabolic syndrome in humans, mechanisms are not yet fully understood. This study aimed at deciphering whether the bacterium exerts its ...
By A-Mansia
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Perchlorate Quantitation in Drinking Water Using Suppressed Anion Chromatography Coupled with Single Quadrupole MS
The EPA has established a Lifetime Drinking Water Health Advisory of 15 ppb for perchlorate to reduce health risks. More than 10 states in U.S. have established heath advisory levels for perchlorate in drinking water ranging from 1 to 18 ppb; for example, California and Maryland have proposed standards of 6 ppb and 1 ppb, respectively. A few quantitative methods for perchlorate have been ...
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How much does a nitrogen generator cost?
Small flow nitrogen generators generally start at around $5000 and can go up to around $10,000. These are systems typically built for small labs or specialized areas in larger labs. Mid-flow nitrogen generators range anywhere between the price of $10,000 and $30,000. Here is a breakdown of the typical long-term cost of a nitrogen generator. If your facility uses nitrogen gas, there is a good ...
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What’s the big deal about ion mobility mass spectrometry?
Ion mobility spectrometry (IMS) is a technique that differentiates ions based on their size, shape, charge, and mass. While often used in small, portable devices at airports and remote locations for rapidly detecting small molecules whose mobility is known (for example, certain narcotics and explosives) when coupled with liquid chromatography-mass spectrometry (LC/MS), IMS provides an orthogonal ...
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Intertek - Case Study
Name: Dr. Torsten Peix Job Title: Technical Operations Manager Company: Intertek Food Services GmbH, Bremen Dr. Torsten Peix outside the lab at Intertek Food Services GmbH Peak Infinity feeds analytical instruments for analysis Intertek is a multinational inspection, product testing and certification company headquartered in London and consisting of many sites around the world. One such ...
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Detection of Low Level of Chloramphenicol in Milk and Honey with MIP SPE and LC-MS-MS
The analysis of chloramphenicol(CAP) is a challenging analysis for drug residues in food matrices. Chloramphenicolis an antibiotic that is effective against a wide range of gram positive and gram negative bacteria in both humans and animals, however potentially fatal side effects such as aplastic anemiaare known in humans. The suspected carcinogenityof CAP is also thought to be dosage ...
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Synthesized heterogeneous Fenton-like goethite (FeOOH) catalyst for degradation of
p -chloronitrobenzeneThe removal of p-chloronitrobenzene (pCNB) was investigated by a heterogeneous Fenton-like system using a laboratory synthesized goethite (FeOOH) as catalyst. The influencing factors and the degradation pathway of pCNB were also evaluated. With a stronger catalytic activity than Fe2+ catalyst, the synthesized FeOOH catalyst can significantly promote the decomposition of H2O2, and the ...
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Efficiency, costs and benefits of AOPs for removal of pharmaceuticals from the water cycle
Different advanced oxidation processes (AOP) were developed for the treatment of highly loaded wastewater streams. Optimisation of removal and improvement of efficiency were carried out on a laboratory, semiworks and pilot plant scale. The persistent cytostatic drug cyclophosphamide was selected as a reference substance regarding elimination and evaluation of the various oxidation processes ...
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Imperial College London explains why they have always used Peak gas generators - Case Study
Mark Bennett, MS Facility manager at Imperial College, tells us how his Genius 3031 nitrogen generator has helped in their Multiple Reaction Monitoring (MRM) based analysis. Name: Mark Bennett Job title: MS Facility manager Company/institution: Imperial College Location: London, UK Imperial College London is a worthy competitor of some of the world’s top universities. It is the only ...
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