UPLC Articles
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Decolorization and degradation of reactive dye during the dyed cotton fabric rinsing process
Dyeing process of textile consumes large quantities of water, which results in huge amounts of colored wastewater. Most of the dye wastewater treating methods focused on the treatment of wastewater after the rinsing process of dyed textile. In this paper, tetraacetylethylenediamine/hydrogen peroxide (TAED/H2O2) active oxidation (AO) system was developed to rinse dyed textile and decolorize the ...
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Photodegradation of the benzothiostrobin in solution and on soil and glass surface
The photolytic characteristics of benzothiostrobin were investigated in solution and on soil and glass surface. The main influence factors such as initial concentration, organic solvent and the aqueous environmental substances, including NO2–, NO3–, Fe2+, Fe3+, H2O2 and turbidity were investigated. Three photodegradation products of benzothiostrobin were identified by ultra-performance liquid ...
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ACQUITY Arc System: Transferring Validated HPLC Methods within USP Guidelines
The thought of transferring established high performance liquid chromatography (HPLC) methods onto a another vendor’s LC, or a new platform like UHPLC/UPLC, may cause a bit of anxiety for those that may be unaware of how easy it can be. The reason that the topic of analytical method transfer induces so much angst is that for the transfer of an LC method to succeed, the method has to work ...
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Impact of polymeric membrane filtration of oil sands process water on organic compounds quantification
The interaction between organic fractions in oil sands process-affected water (OSPW) and three polymeric membranes with varying hydrophilicity (nylon, polyvinylidene fluoride and polytetrafluoroethylene) at different pHs was studied to evaluate the impact of filtration on the quantification of acid-extractable fraction (AEF) and naphthenic acids (NAs). Four functional groups predominated in ...
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Occurrence and removal efficiency of six polycyclic aromatic hydrocarbons in different wastewater treatment plants
Occurrence and removal efficiency of six polycyclic aromatic hydrocarbons (PAHs) (fluoranthene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, benzo[ghi]perylene and indeno[1,2,3-cd]pyrene) in wastewater were monitored at different treatment processes in three wastewater treatment plants (WWTPs) by using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). ...
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What do an ancient Chinese Ruler and Waters’ Mass Spectrometry Research Team have in common?
Tea is very important to them! If Waters Wilmslow ran out of tea it is likely the MS Research Team would struggle to function. The ancient Chinese Ruler, Emperor Jing Di, took tea to the grave with him for a cuppa in the afterlife. Many treasures were found in his tomb including; food, weapons, ceramic animals, and a full size chariot with horses. The discovery included several food items; rice ...
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Ultra-Pure Proof with Mass Detection
Before joining the newly formed Reach Separations in February 2012, I spent five years at AstraZeneca in analysis and purification (latterly as group lead in reversed phase and chiral purification). This experience gives me a good perspective of both the needs of “big pharma” and, more recently, the needs of a specialist separation solution provider. My time at AstraZeneca allowed me ...
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High performance liquid chromatography–tandem mass spectrometry for rapid and sensitive analysis of six polycyclic aromatic hydrocarbons in wastewater
A sensitive and fast method was developed to quantitatively analyse the six polycyclic aromatic hydrocarbons (fluoranthene (FLT), benzo[b]fluoranthene (BbF), benzo[k]fluoranthene (BkF), benzo[a]pyrene (Bap), benzo[ghi]perylene (BghiP) and indeno[1,2,3-cd]pyrene (INPY)) by high performance liquid chromatography (UPLC) coupling with tandem mass spectrometry (MS/MS). Chromatographic separation was ...
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Oxidative transformation of oxcarbazepine by Cl2, ClO2 and O3: characteristics and pathways
In this research, the degradation efficiency, mechanism and intermediates’ toxicities of oxcarbazepine (OXC) upon chlorination, chlorine dioxide oxidation and ozonation were investigated. Results showed that three degradation approaches followed second-order kinetics, and ozonation had the highest removal efficiency both of OXC and dissolved organic carbon (DOC). Reaction intermediates were ...
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Identification and risk assessment of human and veterinary antibiotics in the wastewater treatment plants and the adjacent sea in Tunisia
In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples ...
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Chivas Brothers Limited - Case Study
Name: Alan Rettie Job title: Development Chemist Company: Chivas Brothers Limited (UK) Chivas Brothers, the Scotch whisky subsidiary of French premium spirit conglomerate Pernod Ricard, has 12 operating malt distilleries, a grain distillery, two gin distilleries and over 300 bonded warehouses in the UK, containing an extensive aged inventory of more than six million casks. Chivas Brothers ...
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How Water Treatment Plants Protect Fish from Disruptive Synthetic Hormones
Scottish Water provides 1.34 billion liters of drinking water every day and takes away 847 million liters of waste water daily. Answerable to both the Scottish Parliament and the people of Scotland, Scottish Water recognizes that innovation is a key enabler for them to deliver sustainable, high-quality water treatment services. One of the many compounds they monitor for is the drug class of ...
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Get Empowered: Quickstart Interface - Tip #1
Welcome back to Get Empowered! My tip-of-the-week blog for Empower Software kicks-off by taking a closer look at the Empower QuickStart Interface. There is so much to cover in this series, so I have broken it up in to three tips. Tip #1: An Overview Tip #2: Interactive Help (‘Show me’) Tip #3: Working with Projects and Systems Let’s get started! Tip #1: An Overview The ...
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Simon Fraser University Opens Suite of Mass Spectrometers for Natural Products Discovery Research
As a graduate student at the University of British Columbia, Dr. Roger Linington discovered his future life’s work serendipitously. While studying sponges, it became clear to him that one of the challenges in studying macroorganisms is their limited or slowly replenishing supply. To perform mechanism and mode-of-action studies, he needed a larger, more accessible source of materials. Many ...
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Impact of Cell Culture Media Additives on IgG Glycosylation Produced in Chinese Hamster Ovary Cells
IQVIA recently released a comprehensive overview of the US pharmaceutical market. The report highlighted that despite recent approvals of biosimilars, they are used less than one-third of the time when available. Additionally, at most recent conferences, there have been several dedicated sessions discussing the challenges developing, manufacturing and commercializing biosimilars. Dahodwala and ...
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Advancing Omics Research and Reducing Bias with New MS Technology for Data-Independent Acquisition Experiments
Targeted LC-MS based assays are increasingly applied in the post-discovery Omics area with an emphasis on validation, the first of many phases in translational research; and in studies that are aimed at gaining the understanding of biological systems in terms of drug development and treatment. Understanding the context of analytical results is driving current research, and therefore driving the ...
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Tips to maintain your HPLC & UHPLC systems and columns
Recently, Ade Kujore (Cecil Instruments), Tracie Brombos (GenTech Scientific) and I were asked by Angelo De Palma, a well-respected writer for Lab Manager magazine, to contribute to an article about maintaining and caring about your laboratory instruments. Here are my tips/best practices for column and HPLC/UHPC/UPLC system maintenance. Maintaining your LC columns Proper storage of HPLC ...
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Webinar Highlights: Microfluidics for macromolecules
Hi, I’m Jim Murphy, Principal Consulting Chemist at Waters, and I recently collaborated with Lucinda (Cohen) Hittle to present an exciting webinar on the use of microflow chromatography for macromolecules. Lucinda, a Director of Discovery Bioanalytics at Merck, presented an overview of the use of LC-MS for peptide analysis along with various case studies for in vitro and in vivo studies ...
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Building a Perfect Purification Platform
Dart NeuroScience is one of the largest privately owned biotech companies in San Diego with around 250 employees – and we have an interesting focus: memory. More specifically, our aim is to develop new technologies and therapies that can maintain or improve memory function and cognitive vitality. Much of our research is built on the work of Tim Tully, who was a professor and Head of the ...
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What is electrochemical detection and what are its applications?
Electrochemical detection (ECD) for HPLC or UHPLC / UPLC is an extremely selective and sensitive detection technique that is applied in several analyses such as the neurotransmitters dopamine, serotonin and noradrenalin, or analytes such as 5HIAA, catecholamines and metanephrines. ECD has an enormous linear dynamic range of more than 6 orders of magnitude. This means that concentrations can be ...
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