UPLC technology Articles

  • ACQUITY Arc System: Transferring Validated HPLC Methods within USP Guidelines

    The thought of transferring established high performance liquid chromatography (HPLC) methods onto a another vendor’s LC, or a new platform like UHPLC/UPLC, may cause a bit of anxiety for those that may be unaware of how easy it can be. The reason that the topic of analytical method transfer induces so much angst is that for the transfer of an LC method to succeed, the method has to work as ...


    By Waters Corporation

  • How Water Treatment Plants Protect Fish from Disruptive Synthetic Hormones

    Scottish Water provides 1.34 billion liters of drinking water every day and takes away 847 million liters of waste water daily. Answerable to both the Scottish Parliament and the people of Scotland, Scottish Water recognizes that innovation is a key enabler for them to deliver sustainable, high-quality water treatment services. One of the many compounds they ...


    By Waters Corporation

  • Advancing Omics Research and Reducing Bias with New MS Technology for Data-Independent Acquisition Experiments

    Targeted LC-MS based assays are increasingly applied in the post-discovery Omics area with an emphasis on validation, the first of many phases in translational research; and in studies that are aimed at gaining the understanding of biological systems in terms of drug development and treatment. Understanding the context of analytical results is driving current research, and therefore driving the ...


    By Waters Corporation

  • Simon Fraser University Opens Suite of Mass Spectrometers for Natural Products Discovery Research

    As a graduate student at the University of British Columbia, Dr. Roger Linington discovered his future life’s work serendipitously. While studying sponges, it became clear to him that one of the challenges in studying macroorganisms is their limited or slowly replenishing supply. To perform mechanism and mode-of-action studies, he needed a larger, more accessible source of ...


    By Waters Corporation

  • Ultra-Pure Proof with Mass Detection

    Before joining the newly formed Reach Separations in February 2012, I spent five years at AstraZeneca in analysis and purification (latterly as group lead in reversed phase and chiral purification). This experience gives me a good perspective of both the needs of “big pharma” and, more recently, the needs of a specialist separation solution provider. My ...


    By Waters Corporation

  • High-throughput Microscale Bioanalysis is not a Paradox

    Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in our group knows how to use it!” Maybe even, “there’s no way I can successfully transfer that method, so why ...


    By Waters Corporation

  • The Advantages of a Targeted 2D LC Approach

    Webinar Highlights | Focus on the Relevant: The Advantages of a Targeted 2D Chromatography Approach Hi folks, I’m Daniel Root, Senior Product Marketing Manager for Multidimensional LC Systems at Waters. I recently conducted a webinar that addressed multidimensional liquid chromatography – an exceptional tool for the improvement of characterization and separation of ...


    By Waters Corporation

  • Work Hard. Don’t Quit. Keep an Open Mind. Career Tips for the Analytical Scientist!

    Tips for Making The Analytical Scientist’s Prized PowerList The Analytical Scientist magazine published its PowerList 2016 of the most influential women in the analytical sciences in October. Named to the list was ...


    By Waters Corporation

  • Is Microflow LC a Reality or Perception?

    Microflow or nanoflow chromatography has been used mostly in the academic and fundamental research environment in the past for its various advantages over analytical liquid chromatography, but rarely in the industrial settings. This is most likely because many of us believe it is a pain-in-the-neck technique to perform! But is this a reality or just a ...


    By Waters Corporation

  • Building a Perfect Purification Platform

    Dart NeuroScience is one of the largest privately owned biotech companies in San Diego with around 250 employees – and we have an interesting focus: memory. More specifically, our aim is to develop new technologies and therapies that can maintain or improve memory function and cognitive vitality. Much of our research is built on the work of ...


    By Waters Corporation

  • Chivas Brothers Limited - Case Study

    Name: Alan Rettie Job title: Development Chemist Company: Chivas Brothers Limited (UK) ...

  • Mercaptan Odor Control - CAIROX® Potassium Permanganate

    In municipal and industrial waste treatment, hydrogen sulfide is not the only offensive gas generated from anaerobic decomposition. Mercaptans (RSH) are the organic equivalent to hydrogen sulfide and more odorous at 1/1000th the concentration. Mercaptans are naturally occurring from the degradation of sulfur containing organics (proteins, etc.). A table of commonly found mercaptans is presented ...


    By Carus Corporation

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