Keywords: albumin microspheres, labelling methods, 188Re, radiotherapy, endoradiotherapy, tumours, radiolabelling, beta emitters, hepatocellular carcinoma
Labelling of albumin microspheres with 188Re: a possible agent for radiotherapy
Regional administration of labelled particles by intra-arterial infusion is an effective method for endoradiotherapy of tumours. The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter 188Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was studied. Under optimised conditions, after 60 min reaction time, at 95°C, the reaction yield was more than 95%. Labelled microspheres were found to be stable in vitro; 43 h after labelling, 87% of 188Re was bound to the microspheres.