Secondary metabolites, or biochemical indicators of fungal development, are of intense interest to humankind due to their pharmaceutical and/or toxic properties. We present here a novel Aspergillus nuclear protein, LaeA, as a global regulator of secondary metabolism in this genus. Deletion of laeA (laeA) blocks the expression of metabolic gene clusters, including the sterigmatocystin (carcinogen), penicillin (antibiotic), and lovastatin (antihypercholesterolemic agent) gene clusters. Conversely, overexpression of laeA triggers increased penicillin and lovastatin gene transcription and subsequent product formation. laeA expression is negatively regulated by AflR, a sterigmatocystin Zn2Cys6 transcription factor, in a unique feedback loop, as well as by two signal transduction elements, protein kinase A and RasA. Although these last two proteins also negatively regulate sporulation, laeA strains show little difference in spore production compared to the wild type, indicating that the primary role of LaeA is to regulate metabolic gene clusters.
- American Society for Microbiology
- Laea, a regulator of secondary metabolism in aspergillus spp.
Environmental regulation found to boost business performance
Well-designed environmental regulation can enhance business competitiveness and job creation, according to a report by the Aldersgate Group. It also shows that businesses can also benefit from increased investment in innovation and skills, along with better quality products and infrastructure, as a result of smart regulation.This has been demonstrated in the UK’s landfill tax triggering significant investment by the waste industry in new infrastructure and services, while cutting the amount of rubbish...
Smart energy needs smarter regulation
As Europe’s smart energy community looks forward to coming together at European Utility Week (EUW) 2016 in Barcelona later this year, Global Smart Grid Federation’s Ronnie Belmans looks at how energy regulation could be refocused to the benefit of the industry and consumers. A recent survey of EUW’s Advisory Board Members revealed that almost 70 per cent of them thought that energy policy and regulation were the biggest blockers to achieving a new energy future. I’m not surprised that...
Retail Strategy: A New Focus on Hazardous Waste Regulations
America’s hazardous waste management program ensures the safe management of hazardous waste from the “cradle to the grave”. Many of these regulations were developed more than three decades ago, so it is important we ensure they continue to effectively protect human health and environment into the future. These regulations were developed primarily for industrial and manufacturing settings, but apply to any non-household facility generating and managing hazardous waste—including some...
Biocidal Products Regulation - White Paper
The European Biocidal Products Regulation (Regulation (EU) No. 528/2012) stipulates that biocidal products may only be made available and used on the market if they are certified in accordance with this regulation. Unlike the previous biocidal products legislation, so-called “in-situ” procedures such as electrolysis, chlorine dioxide and ozone now also fall under this certification requirement. This means that anyone who generates biocidal products “in-situ” is required to have them...
Top International News in Chemical Policy and Regulation
AUSTRALIA Australia Releases Third Consultation Paper Concerning NICNAS Reform: On April 29, 2016, the National Industrial Chemicals Notification and Assessment Scheme (NICNAS) published the third consultation paper on its reform initiative. This consultation paper summarizes the main stakeholder comments on the second consultation paper, and builds on the themes in the second consultation paper to describe key changes to the reform proposals. The third consultation paper provides further details and addresses...