Pharmaceutical and personal care products (PPCPs) encompass a family of compounds used by individuals for health and cosmetic purposes, as well as compounds used by the agricultural industry to maintain health of livestock. The number of individuals who are using these products is increasing which has caused an increase in environmental detection. The effect on humans and the environment is still unknown causing the need for more research on the topic. These contaminates are introduced into local waterways via sewage plants and natural disposal (i.e., animal excrement and landfill waste). This piece demonstrates a method for evaluating PPCPs at parts per billion levels in local waterways using liquid chromatography tandem mass spectrometry (LC-MS/MS).