John Wiley & Sons, Ltd.

Linking survival and biomarker responses over time

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The practical usefulness of biomarkers is limited by the complexity of linking their responses to life‐history traits of the organisms (e.g., survival, growth, reproduction) over time. Here we present a first attempt to simultaneously model biomarker responses and survival over time with a toxicokinetic‐toxicodynamic approach. Even though more work is clearly needed, the present study provides a novel direction for interpreting biomarker responses and dynamically linking them to life‐history traits. Environ Toxicol Chem © 2013 SETAC

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