John Wiley & Sons, Ltd.

Linking survival and biomarker responses over time

The practical usefulness of biomarkers is limited by the complexity of linking their responses to life‐history traits of the organisms (e.g., survival, growth, reproduction) over time. Here we present a first attempt to simultaneously model biomarker responses and survival over time with a toxicokinetic‐toxicodynamic approach. Even though more work is clearly needed, the present study provides a novel direction for interpreting biomarker responses and dynamically linking them to life‐history traits. Environ Toxicol Chem © 2013 SETAC

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