Inderscience Publishers

Low dose response of human lymphocytes in vitro and its dependence on the antioxidant status of donor persons

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The individual responses of persons were studied in vitro by lymphocyte micronucleus assay following X-irradiations of 0.7 and 0.25 Gy. Linear correlations of a different coefficient, R, were found with the normal total antioxidant level (TAS value) of the donors' sera: the higher the antioxidant status the less the radiation-induced micronucleus increment. The cytogenetic effect of low doses could be significantly protected above approximately 1.6 mmol l-1 of TAS. Accordingly, the resistance in population, as it were, could be increased by long-lasting consumption of vitamins C and E when the initial TAS values must have been elevated.

Keywords: low dose, lymphocyte micronuclei, antioxidant level, antioxidant protection

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