Keywords: low dose, lymphocyte micronuclei, antioxidant level, antioxidant protection
Low dose response of human lymphocytes in vitro and its dependence on the antioxidant status of donor persons
The individual responses of persons were studied in vitro by lymphocyte micronucleus assay following X-irradiations of 0.7 and 0.25 Gy. Linear correlations of a different coefficient, R, were found with the normal total antioxidant level (TAS value) of the donors' sera: the higher the antioxidant status the less the radiation-induced micronucleus increment. The cytogenetic effect of low doses could be significantly protected above approximately 1.6 mmol l-1 of TAS. Accordingly, the resistance in population, as it were, could be increased by long-lasting consumption of vitamins C and E when the initial TAS values must have been elevated.