John Wiley & Sons, Ltd.

Methylated phenanthrenes are more potent than phenanthrene in a bioassay of human aryl hydrocarbon receptor (AhR) signaling

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Alkylated polycyclic aromatic hydrocarbons (APAHs) are abundant in petroleum but data regarding their toxicological properties are limited. A survey of all monomethylated phenanthrene structures revealed that they were 2‐5 times more potent than phenanthrene for activation of human aryl hydrocarbon receptor in a yeast bioassay. Phenanthrenes with equatorial methyl groups had the greatest potency. The greater potency of the methylated phenanthrenes highlights the need for more toxicological data on APAHs. Environ Toxicol Chem © 2014 SETAC

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