John Wiley & Sons, Ltd.

Modeling the influence of physicochemical properties on gold nanoparticle uptake and elimination by Daphnia magna

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Monitoring the distribution and subsequent effects of nanoparticle (NP) contaminants in aquatic ecosystems will be pivotal to developing regulations that minimize their environmental footprint. This research focused on the link between NP characteristics and Daphnia magna body burden using gold NPs with different size, shape and surface charge configurations as model particles. Uptake followed first order kinetics across the entire concentration range for all particles except the cationic rods, which demonstrated two distinct uptake patterns. Elimination followed the two‐compartment model for all particle configurations. Multiple regression analysis identified size and surface charge as controlling influences over gold NP uptake and elimination while shape was regarded as inconsequential to both processes. Examination of the lumen‐microvilli interface produced no evidence to indicate assimilation of the gold NPs used in the present study. Instead these NPs were restricted to the gut lumen and the carapace where ingestion efficiency and adsorption were the primary determinants of total body burden. Models developed from our data predict that D. magna will amass a higher body burden of larger cationic gold NPs at high concentration exposures and larger anionic gold NPs at low concentration exposures. A survey of the NP literature revealed that these trends were consistent with observations for certain nanomaterial exposures but could not be applied indiscriminately to all NP types and species. This article is protected by copyright. All rights reserved

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