Inderscience Publishers

Modelling of radiation-induced bystander effect at low dose and low LET

0
We presents a new biophysical model of radiation induced bystander effect applicable to low LET radiation and complementing a previously published model (Nikjoo & Khvostunov, IJRB, 79:43-52, 2003). A detailed analysis of experimental data has been performed for both the high and low LET radiations showing, contrary to the general belief, the existence of a dose response in the bystander effect at very low doses. At very low doses, the model predicts a non-linear dose response. As a corollary it is proposed that the definition of the bystander effect should be modified to take into account extra recipient cells which are hit and survived.

Keywords: bystander modelling, cell survival, cell transformation, signal diffusion, track structure, linear energy transfer radiation, LET radiation, bystander effects, low dose, low radiation, dose response, biophysical models

Customer comments

No comments were found for Modelling of radiation-induced bystander effect at low dose and low LET. Be the first to comment!